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Most cancer tissues displayed weak to moderate cytoplasmic and/or nuclear staining. Several cases of liver, cervix and thyroid cancers showed strong immunoreactivity. Gliomas, several lymphomas and lung cancers were negative.
Fraction of tumor cells in a single case of prostate cancer showed strong cytoplasmic staining while Non-Hodgkin's lymphoma displayed moderate immunoreactivity. A single case of stomach cancer displayed moderate nuclear positivity in fraction of tumor cells. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
FGD2 (HGNC Symbol)
Synonyms
ZFYVE4
Description
FYVE, RhoGEF and PH domain containing 2 (HGNC Symbol)