Cell atlas - CYP39A1 - The Human Protein Atlas

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CYP39A1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	CYP39A1
Gene description	Cytochrome P450, family 39, subfamily A, polypeptide 1
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (hTCEpi, SiHa, U-698)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (hTCEpi, SiHa, U-698) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	CYP39A1
Synonyms
Description	Cytochrome P450, family 39, subfamily A, polypeptide 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is involved in the conversion of cholesterol to bile acids. Its substrates include the oxysterols 25-hydroxycholesterol, 27-hydroxycholesterol and 24-hydroxycholesterol. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Chromosome	6
Cytoband	p12.3
Chromosome location (bp)	46549580 - 46652830
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000146233 (version 83.38)
Entrez gene	51302
UniProt	Q9NYL5 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9NYL5
Antibodypedia	CYP39A1 antibodies

PROTEIN BROWSER

CYP39A1-001	CYP39A1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CYP39A1-001 ENSP00000275016 ENST00000275016	Q9NYL5 [Direct mapping] 24-hydroxycholesterol 7-alpha-hydroxylase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005506 [iron ion binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006699 [bile acid biosynthetic process] GO:0006707 [cholesterol catabolic process] GO:0006805 [xenobiotic metabolic process] GO:0007586 [digestion] GO:0008206 [bile acid metabolic process] GO:0008387 [steroid 7-alpha-hydroxylase activity] GO:0008396 [oxysterol 7-alpha-hydroxylase activity] GO:0016125 [sterol metabolic process] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0030573 [bile acid catabolic process] GO:0033782 [24-hydroxycholesterol 7alpha-hydroxylase activity] GO:0043231 [intracellular membrane-bounded organelle] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	469 aa 54.1 kDa	No	2
CYP39A1-201 ENSP00000477769 ENST00000619708	A0A087WTD2 [Direct mapping] 24-hydroxycholesterol 7-alpha-hydroxylase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0004497 [monooxygenase activity] GO:0005506 [iron ion binding] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0055114 [oxidation-reduction process] Show all	297 aa 34.5 kDa	No	2

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.