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Malignancies showed weak to moderate membranous and cytoplasmic immunoreactivity. Colorectal, pancreatic and liver cancers along with several gastric cancers were strongly stained. Malignant gliomas were negative.
GENE INFORMATION
Gene name
TPBG (HGNC Symbol)
Synonyms
5T4, 5T4-AG
Description
Trophoblast glycoprotein (HGNC Symbol)
Entrez gene summary
This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009]
