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PHIP

GENERAL INFORMATION

Gene name

 PHIP

Gene description

 Pleckstrin homology domain interacting protein

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 2 antibodies.
HPA019140 , HPA019838
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PHIP (HGNC Symbol)

Synonyms

 BRWD2, DCAF14, FLJ20705, ndrp, WDR11

Description

 Pleckstrin homology domain interacting protein (HGNC Symbol)

Entrez gene summary

 PHIP binds the pleckstrin homology (PH) domain of insulin receptor substrate-1 (IRS1; MIM 147545), modulates insulin signaling, and plays a role in pancreatic beta cell growth and survival (Farhang-Fallah et al., 2000 [PubMed 11018022]; Podcheko et al., 2007 [PubMed 17636024]).[supplied by OMIM, Jun 2009]

Chromosome

 6

Cytoband

 q14.1

Chromosome location (bp)

 78935867 - 79078236

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000146247 (version 83.38)

Entrez gene

 55023

UniProt

 Q8WWQ0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WWQ0

Antibodypedia

 PHIP antibodies

PROTEIN BROWSER
PHIP-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PHIP-001
ENSP00000275034
ENST00000275034
Q8WWQ0 [Direct mapping]
PH-interacting protein
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001932 [regulation of protein phosphorylation]
GO:0005158 [insulin receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006606 [protein import into nucleus]
GO:0007010 [cytoskeleton organization]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008360 [regulation of cell shape]
GO:0010800 [positive regulation of peptidyl-threonine phosphorylation]
GO:0022604 [regulation of cell morphogenesis]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0040008 [regulation of growth]
GO:0043066 [negative regulation of apoptotic process]
GO:0043568 [positive regulation of insulin-like growth factor receptor signaling pathway]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0070062 [extracellular exosome]
GO:0070577 [lysine-acetylated histone binding]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
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 1821 aa
206.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.