Cell atlas - TMEM181 - The Human Protein Atlas

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TMEM181

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus
	Vesicles

Human cell
	Golgi Apparatus
	Vesicles

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GENERAL INFORMATION
Gene name	TMEM181
Gene description	Transmembrane protein 181
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to vesicles. In addition localized to the Golgi apparatus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved)
Additional location	In addition localized to the Golgi apparatus (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA040189
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to vesicles. In addition localized to the Golgi apparatus.

Main location

Vesicles (approved)

Additional location

Golgi apparatus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA040189	A-431	Vesicles
	HPA040189	U-2 OS	Vesicles
	HPA040189	U-251 MG	Golgi apparatus
	HPA040189	U-251 MG	Vesicles

GENE INFORMATION
Gene name	TMEM181 (HGNC Symbol)
Synonyms	GPR178, KIAA1423
Description	Transmembrane protein 181 (HGNC Symbol)
Entrez gene summary	The TMEM181 gene encodes a putative G protein-coupled receptor expressed on the cell surface (Carette et al., 2009 [PubMed 19965467]; Wollscheid et al., 2009 [PubMed 19349973]).[supplied by OMIM, Jan 2010]
Chromosome	6
Cytoband	q25.3
Chromosome location (bp)	158536436 - 158635428
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000146433 (version 83.38)
Entrez gene	57583
UniProt	Q9P2C4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9P2C4
Antibodypedia	TMEM181 antibodies

PROTEIN BROWSER

TMEM181-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMEM181-001 ENSP00000356057 ENST00000367090	Q9P2C4 [Direct mapping] Transmembrane protein 181 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0009405 [pathogenesis] GO:0015643 [toxic substance binding] GO:0016021 [integral component of membrane] Show all	612 aa 69.3 kDa	No	8

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.