Cell atlas - CREB5 - The Human Protein Atlas

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CREB5

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus
	Plasma membrane
	Vesicles

Human cell
	Nucleoplasm
	Plasma Membrane
	Vesicles

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GENERAL INFORMATION
Gene name	CREB5
Gene description	CAMP responsive element binding protein 5
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus & plasma membrane. In addition localized to vesicles.
RNA cell category	Cell line enhanced (HL-60)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved), Plasma membrane (approved)
Additional location	In addition localized to the Vesicles (approved)

DATA RELIABILITY
Reliability score	Approved based on 2 antibodies. HPA050020 , HPA061622
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HL-60) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus & plasma membrane. In addition localized to vesicles.

Main location

Nucleus (approved), Plasma membrane (approved)

Additional location

Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA050020	HEK 293	Nucleus
HPA050020	HEK 293	Plasma membrane
HPA050020	PC-3	Nucleoplasm
HPA050020	PC-3	Plasma membrane
HPA050020	U-2 OS	Nucleoplasm
HPA061622	HEK 293	Nucleus
HPA061622	HEK 293	Vesicles
HPA061622	PC-3	Nucleoplasm
HPA061622	PC-3	Plasma membrane
HPA061622	U-2 OS	Nucleoplasm
HPA061622	U-2 OS	Vesicles

GENE INFORMATION
Gene name	CREB5 (HGNC Symbol)
Synonyms	CRE-BPA, H_GS165L15.1
Description	CAMP responsive element binding protein 5 (HGNC Symbol)
Entrez gene summary	The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family contain zinc-finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband
Chromosome location (bp)	28299321 - 28825894
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000146592 (version 83.38)
Entrez gene	9586
UniProt	Q02930 (UniProt - Evidence at protein level)
neXtProt	NX_Q02930
Antibodypedia	CREB5 antibodies

PROTEIN BROWSER

CREB5-001	CREB5-002	CREB5-003	CREB5-004	CREB5-005	CREB5-008	CREB5-012	CREB5-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CREB5-001 ENSP00000350359 ENST00000357727	Q02930 [Direct mapping] Cyclic AMP-responsive element-binding protein 5 Show all	Predicted intracellular proteins Transcription factors Basic domains Protein evidence (Kim et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0043565 [sequence-specific DNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	508 aa 56.9 kDa	No	0
CREB5-002 ENSP00000379594 ENST00000396300	Q02930 [Direct mapping] Cyclic AMP-responsive element-binding protein 5 Show all	Predicted intracellular proteins Transcription factors Basic domains Protein evidence (Kim et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0043565 [sequence-specific DNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	501 aa 56 kDa	No	0
CREB5-003 ENSP00000379592 ENST00000396298	Q02930 [Direct mapping] Cyclic AMP-responsive element-binding protein 5 Show all	Predicted intracellular proteins Transcription factors Basic domains Protein evidence (Kim et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0043565 [sequence-specific DNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	369 aa 41.2 kDa	No	0
CREB5-004 ENSP00000387197 ENST00000409603	Q02930 [Direct mapping] Cyclic AMP-responsive element-binding protein 5 Show all	Predicted intracellular proteins Transcription factors Basic domains Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0043565 [sequence-specific DNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	475 aa 53.1 kDa	No	0
CREB5-005 ENSP00000379593 ENST00000396299	Q02930 [Direct mapping] Cyclic AMP-responsive element-binding protein 5 Show all	Predicted intracellular proteins Transcription factors Basic domains Protein evidence (Kim et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0043565 [sequence-specific DNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	475 aa 53.1 kDa	No	0
CREB5-008 ENSP00000394088 ENST00000424599	H9KVC5 [Direct mapping] Cyclic AMP-responsive element-binding protein 5 Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0046872 [metal ion binding] Show all	115 aa 13.1 kDa	No	0
CREB5-012 ENSP00000394979 ENST00000426500	C9JN33 [Direct mapping] Cyclic AMP-responsive element-binding protein 5 Show all	Predicted intracellular proteins Show all		212 aa 24 kDa	No	0
CREB5-015 ENSP00000440429 ENST00000498316	H0YFV2 [Direct mapping] Cyclic AMP-responsive element-binding protein 5 Show all	Predicted intracellular proteins Show all		39 aa 4.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.