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PURB

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GENERAL INFORMATION

Gene name

 PURB

Gene description

 Purine-rich element binding protein B

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleus.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA048766
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleus.

Main location

 Nucleus (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA048766 MCF7 Nucleoplasm
HPA048766 U-2 OS Nucleus
HPA048766 U-251 MG Nucleoplasm

GENE INFORMATION

Gene name

 PURB (HGNC Symbol)

Synonyms

 PURBETA

Description

 Purine-rich element binding protein B (HGNC Symbol)

Entrez gene summary

 This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 p13

Chromosome location (bp)

 44876293 - 44885361

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000146676 (version 83.38)

Entrez gene

 5814

UniProt

 Q96QR8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96QR8

Antibodypedia

 PURB antibodies

PROTEIN BROWSER
PURB-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PURB-001
ENSP00000379051
ENST00000395699
Q96QR8 [Direct mapping]
Transcriptional activator protein Pur-beta
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Predicted intracellular proteins
Transcription factors
   Yet undefined DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005662 [DNA replication factor A complex]
GO:0006351 [transcription, DNA-templated]
GO:0008134 [transcription factor binding]
GO:0008283 [cell proliferation]
GO:0030154 [cell differentiation]
GO:0044822 [poly(A) RNA binding]
GO:0045637 [regulation of myeloid cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046332 [SMAD binding]
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 312 aa
33.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.