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LUC7L2

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GENERAL INFORMATION

Gene name

 LUC7L2

Gene description

 LUC7-like 2 pre-mRNA splicing factor

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleus. Caution: Based on antibodies targeting proteins from multiple genes.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA051631
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleus. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

 Nucleus (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

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Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA051631 HeLa Nucleoplasm
HPA051631 MCF7 Nucleus
HPA051631 U-2 OS Nucleus

GENE INFORMATION

Gene name

 LUC7L2 (HGNC Symbol)

Synonyms

 CGI-59, CGI-74, FLJ10657, hLuc7B2, H_NH0792N18.3, LUC7B2

Description

 LUC7-like 2 pre-mRNA splicing factor (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that contains a C2H2-type zinc finger, coiled-coil region and arginine, serine-rich (RS) domain. A similar protein in mouse interacts with sodium channel modifier 1, and the encoded protein may be involved in the recognition of non-consensus splice donor sites in association with the U1 snRNP spliceosomal subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

Chromosome

 7

Cytoband

 q34

Chromosome location (bp)

 139340359 - 139423457

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000146963 (version 83.38)

Entrez gene

 51631

UniProt

 Q9Y383 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y383

Antibodypedia

 LUC7L2 antibodies

PROTEIN BROWSER
LUC7L2-001
LUC7L2-005
LUC7L2-201
LUC7L2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LUC7L2-001
ENSP00000347005
ENST00000354926
Q9Y383 [Target identity:100%; Query identity:100%]
Putative RNA-binding protein Luc7-like 2
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003729 [mRNA binding]
GO:0005515 [protein binding]
GO:0005685 [U1 snRNP]
GO:0006376 [mRNA splice site selection]
GO:0016607 [nuclear speck]
GO:0019899 [enzyme binding]
GO:0044822 [poly(A) RNA binding]
GO:0071004 [U2-type prespliceosome]
Show all
 392 aa
46.5 kDa 		No 0
LUC7L2-005
ENSP00000441604
ENST00000541170
A0A0A6YYC3 [Direct mapping]
Protein C7orf55-LUC7L2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003729 [mRNA binding]
GO:0005685 [U1 snRNP]
GO:0006376 [mRNA splice site selection]
Show all
 389 aa
46.2 kDa 		No 0
LUC7L2-201
ENSP00000263545
ENST00000263545
A0A0A6YYC3 [Direct mapping]
Protein C7orf55-LUC7L2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003729 [mRNA binding]
GO:0005685 [U1 snRNP]
GO:0006376 [mRNA splice site selection]
Show all
 389 aa
46.2 kDa 		No 0
LUC7L2-202
ENSP00000483438
ENST00000619796
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003729 [mRNA binding]
GO:0005685 [U1 snRNP]
GO:0006376 [mRNA splice site selection]
Show all
 391 aa
46.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.