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TMEM27

GENERAL INFORMATION

Gene name

 TMEM27

Gene description

 Transmembrane protein 27

Protein class

 Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (kidney)
GTEx:Tissue enriched (kidney)
FANTOM5:Tissue enriched (kidney)

Protein evidence

 Evidence at protein level

Protein expression

 Low cytoplasmic and luminal membrane expression in renal tubules. Additional cytoplasmic expression in pancreatic isletes.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA048543
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Esophagus
N/A
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (kidney)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (kidney)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (kidney)

GENE INFORMATION

Gene name

 TMEM27 (HGNC Symbol)

Synonyms

 NX17

Description

 Transmembrane protein 27 (HGNC Symbol)

Entrez gene summary

 This gene encodes a type 1 transmembrane protein that is important for trafficking amino acid transporters to the apical brush border of proximal tubules. The encoded protein binds to amino acid transporters and regulates their expression on the plasma membrane. It also plays a role in controlling insulin exocytosis by regulating formation of the SNARE (soluble N-ethylmaleimide-sensitive-factor attachment protein receptor) complex in pancreatic beta cells. The extracellular domain of the encoded protein may be cleaved and shed from the plasma membrane specifically in pancreatic beta cells. [provided by RefSeq, Jun 2013]

Chromosome

 X

Cytoband

 p22.2

Chromosome location (bp)

 15627318 - 15665031

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000147003 (version 83.38)

Entrez gene

 57393

UniProt

 Q9HBJ8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9HBJ8

Antibodypedia

 TMEM27 antibodies

PROTEIN BROWSER
TMEM27-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TMEM27-001
ENSP00000369699
ENST00000380342
Q9HBJ8 [Direct mapping]
Collectrin
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0008237 [metallopeptidase activity]
GO:0008241 [peptidyl-dipeptidase activity]
GO:0016021 [integral component of membrane]
GO:0031526 [brush border membrane]
GO:0035543 [positive regulation of SNARE complex assembly]
GO:0035774 [positive regulation of insulin secretion involved in cellular response to glucose stimulus]
GO:0045956 [positive regulation of calcium ion-dependent exocytosis]
GO:0051957 [positive regulation of amino acid transport]
GO:0070062 [extracellular exosome]
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 222 aa
25.2 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.