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AKAP4

GENERAL INFORMATION

Gene name

 AKAP4

Gene description

 A kinase (PRKA) anchor protein 4

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (testis)
GTEx:Tissue enriched (testis)
FANTOM5:Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression

 Selective expression in spermatids of seminiferus ducts.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA005949 , HPA020046
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)

GENE INFORMATION

Gene name

 AKAP4 (HGNC Symbol)

Synonyms

 AKAP82, CT99, Fsc1, hAKAP82, HI, p82

Description

 A kinase (PRKA) anchor protein 4 (HGNC Symbol)

Entrez gene summary

 The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is localized to the sperm flagellum and may be involved in the regulation of sperm motility. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

 p11.22

Chromosome location (bp)

 50190768 - 50201013

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000147081 (version 83.38)

Entrez gene

 8852

UniProt

 Q5JQC9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q5JQC9

Antibodypedia

 AKAP4 antibodies

PROTEIN BROWSER
AKAP4-001
AKAP4-002
AKAP4-003
AKAP4-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AKAP4-001
ENSP00000351327
ENST00000358526
Q5JQC9 [Direct mapping]
A-kinase anchor protein 4
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005929 [cilium]
GO:0005952 [cAMP-dependent protein kinase complex]
GO:0006928 [movement of cell or subcellular component]
GO:0007165 [signal transduction]
GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway]
GO:0007338 [single fertilization]
GO:0008104 [protein localization]
GO:0010738 [regulation of protein kinase A signaling]
GO:0030018 [Z disc]
GO:0030317 [sperm motility]
GO:0031514 [motile cilium]
GO:0035686 [sperm fibrous sheath]
GO:0044458 [motile cilium assembly]
GO:0045184 [establishment of protein localization]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051018 [protein kinase A binding]
GO:0097228 [sperm principal piece]
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 854 aa
94.5 kDa 		No 0
AKAP4-002
ENSP00000365232
ENST00000376064
Q5JQC9 [Direct mapping]
A-kinase anchor protein 4
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005952 [cAMP-dependent protein kinase complex]
GO:0006928 [movement of cell or subcellular component]
GO:0007165 [signal transduction]
GO:0007338 [single fertilization]
GO:0010738 [regulation of protein kinase A signaling]
GO:0030317 [sperm motility]
GO:0031514 [motile cilium]
GO:0035686 [sperm fibrous sheath]
GO:0051018 [protein kinase A binding]
GO:0097228 [sperm principal piece]
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 845 aa
93.4 kDa 		No 0
AKAP4-003
ENSP00000402403
ENST00000448865
A0A075B6Q6 [Direct mapping]
A-kinase anchor protein 4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0010738 [regulation of protein kinase A signaling]
GO:0035686 [sperm fibrous sheath]
GO:0097228 [sperm principal piece]
Show all
 213 aa
23.7 kDa 		No 0
AKAP4-004
ENSP00000412279
ENST00000437370
A0A075B6R4 [Direct mapping]
A-kinase anchor protein 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0010738 [regulation of protein kinase A signaling]
GO:0035686 [sperm fibrous sheath]
GO:0097228 [sperm principal piece]
Show all
 254 aa
28.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.