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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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CCNB3
  • TISSUE

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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

CCNB3

Gene description

Cyclin B3

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Group enriched (testis, epididymis)
GTEx:Tissue enriched (testis)
FANTOM5:Group enriched (testis, pituitary gland)

Protein evidence

Evidence at protein level

Protein expression

Nuclear and cytoplasmic expression in seminiferous ducts in testis.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

Approved based on 1 antibody.
HPA000496
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (testis, epididymis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (testis, pituitary gland)

GENE INFORMATION

Gene name

CCNB3

Synonyms

Description

Cyclin B3 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as positive regulators of cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle. Different cyclins exhibit distinct expression and degradation patterns, which contribute to the temporal coordination of each mitotic event. Studies of similar genes in chicken and drosophila suggest that this cyclin may associate with CDC2 and CDK2 kinases, and may be required for proper spindle reorganization and restoration of the interphase nucleus. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

Chromosome

X

Cytoband

p11.22

Chromosome location (bp)

50202713 - 50351910

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000147082 (version 83.38)

Entrez gene

85417

UniProt

Q8WWL7 (UniProt - Evidence at protein level)

neXtProt

NX_Q8WWL7

Antibodypedia

CCNB3 antibodies

PROTEIN BROWSER

CCNB3-001
CCNB3-002
CCNB3-201
CCNB3-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CCNB3-001
ENSP00000365210
ENST00000376042
Q8WWL7 [Direct mapping]
G2/mitotic-specific cyclin-B3
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0051301 [cell division]
GO:0051321 [meiotic cell cycle]
Show all
1395 aa
157.9 kDa
No 0
CCNB3-002
ENSP00000365206
ENST00000376038
Q8WWL7 [Direct mapping]
G2/mitotic-specific cyclin-B3
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0051301 [cell division]
GO:0051321 [meiotic cell cycle]
Show all
291 aa
33.3 kDa
No 0
CCNB3-201
ENSP00000276014
ENST00000276014
Q8WWL7 [Direct mapping]
G2/mitotic-specific cyclin-B3
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0051301 [cell division]
GO:0051321 [meiotic cell cycle]
Show all
1395 aa
157.9 kDa
No 0
CCNB3-202
ENSP00000338682
ENST00000348603
Q8WWL7 [Direct mapping]
G2/mitotic-specific cyclin-B3
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0051301 [cell division]
GO:0051321 [meiotic cell cycle]
Show all
291 aa
33.3 kDa
No 0

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The Human Protein Atlas project is funded
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