Tissue expression of SLC16A2 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SLC16A2
Gene description	Solute carrier family 16, member 2 (thyroid hormone transporter)
Protein class	Disease related genes Plasma proteins Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	SLC16A2 (HGNC Symbol)
Synonyms	AHDS, DXS128, MCT7, MCT8, MRX22, XPCT
Description	Solute carrier family 16, member 2 (thyroid hormone transporter) (HGNC Symbol)
Entrez gene summary	This gene encodes an integral membrane protein that functions as a transporter of thyroid hormone. The encoded protein facilitates the cellular importation of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). This gene is expressed in many tissues and likely plays an important role in the development of the central nervous system. Loss of function mutations in this gene are associated with psychomotor retardation in males while females exhibit no neurological defects and more moderate thyroid-deficient phenotypes. This gene is subject to X-chromosome inactivation. Mutations in this gene are the cause of Allan-Herndon-Dudley syndrome. [provided by RefSeq, Mar 2012]
Chromosome	X
Cytoband	q13.2
Chromosome location (bp)	74421461 - 74533917
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000147100 (version 83.38)
Entrez gene	6567
UniProt	P36021 (UniProt - Evidence at protein level)
neXtProt	NX_P36021
Antibodypedia	SLC16A2 antibodies

PROTEIN BROWSER

SLC16A2-001	SLC16A2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC16A2-001 ENSP00000465734 ENST00000587091	P36021 [Direct mapping] Monocarboxylate transporter 8 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0005215 [transporter activity] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0008028 [monocarboxylic acid transmembrane transporter activity] GO:0015293 [symporter activity] GO:0015349 [thyroid hormone transmembrane transporter activity] GO:0015718 [monocarboxylic acid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070327 [thyroid hormone transport] Show all	539 aa 59.5 kDa	No	>9
SLC16A2-002 ENSP00000466213 ENST00000590447	K7ELT4 [Direct mapping] Monocarboxylate transporter 8 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005887 [integral component of plasma membrane] GO:0015349 [thyroid hormone transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070327 [thyroid hormone transport] Show all	229 aa 25.5 kDa	No	6