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IL2RG

GENERAL INFORMATION

Gene name

 IL2RG

Gene description

 Interleukin 2 receptor, gamma

Protein class

 Cancer-related genes
CD markers
Disease related genes
FDA approved drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (tonsil, lymph node)
GTEx:Tissue enhanced (spleen, small intestine)
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 High cytoplasmic expression in a subset of immune cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA046641
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (tonsil, lymph node)
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin050100150200250300TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen, small intestine)
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin020406080100RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina050100150200250300Tags Per Million

GENE INFORMATION

Gene name

 IL2RG (HGNC Symbol)

Synonyms

 CD132, CIDX, IMD4, SCIDX1

Description

 Interleukin 2 receptor, gamma (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder. [provided by RefSeq, Mar 2010]

Chromosome

 X

Cytoband

 q13.1

Chromosome location (bp)

 71107404 - 71112108

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000147168 (version 83.38)

Entrez gene

 3561

UniProt

 P31785 (UniProt - Evidence at protein level)

neXtProt

 NX_P31785

Antibodypedia

 IL2RG antibodies

PROTEIN BROWSER
IL2RG-001
IL2RG-002
IL2RG-003
IL2RG-004
IL2RG-005
IL2RG-201
IL2RG-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IL2RG-001
ENSP00000423966
ENST00000487883
D6RBW5 [Direct mapping]
Cytokine receptor common subunit gamma
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 176 aa
20.8 kDa 		No 0
IL2RG-002
ENSP00000423601
ENST00000473378
D6R964 [Direct mapping]
Cytokine receptor common subunit gamma
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
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 99 aa
11.2 kDa 		No 0
IL2RG-003
ENSP00000421262
ENST00000482750
H0Y8J6 [Direct mapping]
Cytokine receptor common subunit gamma
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0016020 [membrane]
GO:0019221 [cytokine-mediated signaling pathway]
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 65 aa
7.6 kDa 		No 0
IL2RG-004
ENSP00000363318
ENST00000374202
P31785 [Direct mapping]
Cytokine receptor common subunit gamma
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004896 [cytokine receptor activity]
GO:0004911 [interleukin-2 receptor activity]
GO:0004913 [interleukin-4 receptor activity]
GO:0004917 [interleukin-7 receptor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019976 [interleukin-2 binding]
GO:0019982 [interleukin-7 binding]
GO:0035771 [interleukin-4-mediated signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038110 [interleukin-2-mediated signaling pathway]
GO:0038111 [interleukin-7-mediated signaling pathway]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 369 aa
42.3 kDa 		Yes 1
IL2RG-005
ENSP00000425233
ENST00000464642
D6RDW9 [Direct mapping]
Cytokine receptor common subunit gamma
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0016020 [membrane]
GO:0019221 [cytokine-mediated signaling pathway]
Show all
 220 aa
26.1 kDa 		No 0
IL2RG-201
ENSP00000363303
ENST00000374188
Q5FC10 [Direct mapping]
Cytokine receptor common subunit gamma; IL2RG nirs variant 4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 98 aa
10.8 kDa 		No 0
IL2RG-202
ENSP00000388967
ENST00000456850
P31785 [Direct mapping]
Cytokine receptor common subunit gamma
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004896 [cytokine receptor activity]
GO:0004911 [interleukin-2 receptor activity]
GO:0004913 [interleukin-4 receptor activity]
GO:0004917 [interleukin-7 receptor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009897 [external side of plasma membrane]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019976 [interleukin-2 binding]
GO:0035771 [interleukin-4-mediated signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038110 [interleukin-2-mediated signaling pathway]
GO:0038111 [interleukin-7-mediated signaling pathway]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 179 aa
20.1 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.