Cell atlas - IGSF1 - The Human Protein Atlas

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IGSF1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	IGSF1
Gene description	Immunoglobulin superfamily, member 1
Protein class	Disease related genes Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Cell line enhanced (SH-SY5Y, Hep G2)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA035582
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SH-SY5Y, Hep G2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA035582	Hep G2	Cytosol
	HPA035582	U-2 OS	Cytosol
	HPA035582	U-251 MG	Cytosol

GENE INFORMATION
Gene name	IGSF1 (HGNC Symbol)
Synonyms	IGCD1, IGDC1, INHBP, KIAA0364, MGC75490, PGSF2
Description	Immunoglobulin superfamily, member 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the immunoglobulin-like domain-containing superfamily. Proteins in this superfamily contain varying numbers of immunoglobulin-like domains and are thought to participate in the regulation of interactions between cells. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]
Chromosome	X
Cytoband
Chromosome location (bp)	131273506 - 131578899
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000147255 (version 83.38)
Entrez gene	3547
UniProt	Q8N6C5 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N6C5
Antibodypedia	IGSF1 antibodies

PROTEIN BROWSER

IGSF1-001	IGSF1-002	IGSF1-003	IGSF1-004	IGSF1-007	IGSF1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IGSF1-001 ENSP00000359941 ENST00000370904	Q8N6C5 [Direct mapping] Immunoglobulin superfamily member 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006355 [regulation of transcription, DNA-templated] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034711 [inhibin binding] Show all	1327 aa 148 kDa	Yes	3
IGSF1-002 ENSP00000359947 ENST00000370910	Q8N6C5 [Direct mapping] Immunoglobulin superfamily member 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006355 [regulation of transcription, DNA-templated] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034711 [inhibin binding] Show all	1327 aa 148 kDa	Yes	3
IGSF1-003 ENSP00000355010 ENST00000361420	Q8N6C5 [Direct mapping] Immunoglobulin superfamily member 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006355 [regulation of transcription, DNA-templated] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034711 [inhibin binding] Show all	1336 aa 148.9 kDa	Yes	3
IGSF1-004 ENSP00000359938 ENST00000370901	Q8N6C5 [Direct mapping] Immunoglobulin superfamily member 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006355 [regulation of transcription, DNA-templated] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034711 [inhibin binding] Show all	242 aa 27.2 kDa	Yes	0
IGSF1-007 ENSP00000359937 ENST00000370900	Q8N6C5 [Direct mapping] Immunoglobulin superfamily member 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006355 [regulation of transcription, DNA-templated] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034711 [inhibin binding] Show all	242 aa 27.2 kDa	Yes	0
IGSF1-201 ENSP00000359940 ENST00000370903	Q8N6C5 [Direct mapping] Immunoglobulin superfamily member 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006355 [regulation of transcription, DNA-templated] GO:0007165 [signal transduction] GO:0015026 [coreceptor activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034711 [inhibin binding] Show all	1341 aa 149.4 kDa	Yes	3

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.