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RBMX

GENERAL INFORMATION

Gene name

 RBMX

Gene description

 RNA binding motif protein, X-linked

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous nuclear expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 1 antibody.
HPA057707
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 RBMX (HGNC Symbol)

Synonyms

 hnRNP-G, HNRNPG, RNMX

Description

 RNA binding motif protein, X-linked (HGNC Symbol)

Entrez gene summary

 This gene belongs to the RBMY gene family which includes candidate Y chromosome spermatogenesis genes. This gene, an active X chromosome homolog of the Y chromosome RBMY gene, is widely expressed whereas the RBMY gene evolved a male-specific function in spermatogenesis. Pseudogenes of this gene, found on chromosomes 1, 4, 9, 11, and 6, were likely derived by retrotransposition from the original gene. Alternatively spliced transcript variants encoding different isoforms have been identified. A snoRNA gene (SNORD61) is found in one of its introns. [provided by RefSeq, Sep 2009]

Chromosome

 X

Cytoband

 q26.3

Chromosome location (bp)

 136848004 - 136880764

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000147274 (version 83.38)

Entrez gene

 27316

UniProt

 P38159 (UniProt - Evidence at protein level)

neXtProt

 NX_P38159

Antibodypedia

 RBMX antibodies

PROTEIN BROWSER
RBMX-001
RBMX-003
RBMX-005
RBMX-006
RBMX-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RBMX-001
ENSP00000359645
ENST00000320676
P38159 [Direct mapping]
RNA-binding motif protein, X chromosome RNA-binding motif protein, X chromosome, N-terminally processed
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000381 [regulation of alternative mRNA splicing, via spliceosome]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0001047 [core promoter binding]
GO:0001649 [osteoblast differentiation]
GO:0003676 [nucleic acid binding]
GO:0003682 [chromatin binding]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005719 [nuclear euchromatin]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006509 [membrane protein ectodomain proteolysis]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0030529 [ribonucleoprotein complex]
GO:0044530 [supraspliceosomal complex]
GO:0044822 [poly(A) RNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048025 [negative regulation of mRNA splicing, via spliceosome]
GO:0048026 [positive regulation of mRNA splicing, via spliceosome]
GO:0051260 [protein homooligomerization]
GO:0070062 [extracellular exosome]
GO:0071013 [catalytic step 2 spliceosome]
GO:0071347 [cellular response to interleukin-1]
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 391 aa
42.3 kDa 		No 0
RBMX-003
ENSP00000411989
ENST00000431446
P38159 [Direct mapping]
RNA-binding motif protein, X chromosome RNA-binding motif protein, X chromosome, N-terminally processed
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000381 [regulation of alternative mRNA splicing, via spliceosome]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0001047 [core promoter binding]
GO:0001649 [osteoblast differentiation]
GO:0003676 [nucleic acid binding]
GO:0003682 [chromatin binding]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005719 [nuclear euchromatin]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006509 [membrane protein ectodomain proteolysis]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0030529 [ribonucleoprotein complex]
GO:0044530 [supraspliceosomal complex]
GO:0044822 [poly(A) RNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048025 [negative regulation of mRNA splicing, via spliceosome]
GO:0048026 [positive regulation of mRNA splicing, via spliceosome]
GO:0051260 [protein homooligomerization]
GO:0070062 [extracellular exosome]
GO:0071013 [catalytic step 2 spliceosome]
GO:0071347 [cellular response to interleukin-1]
Show all
 196 aa
22.2 kDa 		No 0
RBMX-005
ENSP00000457866
ENST00000565438
H3BUY5 [Direct mapping]
RNA-binding motif protein, X chromosome
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
 263 aa
28.7 kDa 		No 0
RBMX-006
ENSP00000457051
ENST00000562646
H3BT71 [Direct mapping]
RNA-binding motif protein, X chromosome
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
Show all
 296 aa
32.2 kDa 		No 0
RBMX-007
ENSP00000405117
ENST00000419968
H0Y6E7 [Direct mapping]
RNA-binding motif protein, X chromosome
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
Show all
 292 aa
31.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.