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Selected cases of breast, urothelial and gynaecological cancers showed moderate to strong cytoplasmic positivity. Remaining tumor cells were generally negative.
Most malignant tissues showed moderate to strong cytoplasmic staining. The malignant carcinoids were generally negative.
GENE INFORMATION
Gene name
ZNF185
Synonyms
Description
Zinc finger protein 185 (LIM domain) (HGNC Symbol)
Entrez gene summary
Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This gene encodes a LIM-domain zinc finger protein. The LIM domain is composed of two contiguous zinc finger domains, separated by a two-amino acid residue hydrophobic linker. The LIM domain mediates protein:protein interactions. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, May 2010]
