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Term
Gene name

Class

Subclass

Chromosome

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In atlas

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Reliability

Reliability

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Method

Validation

Method

Validation

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Searches

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Specificity

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Detectable

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GNRH1
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

GNRH1

Gene description

Gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)

Protein class

Disease related genes
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Mixed
GTEx:Expressed in all
FANTOM5:Tissue enriched (caudate)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in a subset of neurons in hypothalamus.

DATA RELIABILITY

Data reliability
description

Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Presumed off target binding observed and disregarded.

Reliability score

Approved based on 1 antibody.
HPA027532
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Hypothalamus
N/A
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Hypothalamus

Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical
HypothalamusCerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin024681012TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin0246810RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (caudate)
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina0246810Tags Per Million

GENE INFORMATION

Gene name

GNRH1 (HGNC Symbol)

Synonyms

GNRH, GRH, LHRH

Description

Gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) (HGNC Symbol)

Entrez gene summary

This gene encodes a preproprotein that is proteolytically processed to generate a peptide that is a member of the gonadotropin-releasing hormone (GnRH) family of peptides. Alternative splicing results in multiple transcript variants, at least one of which is secreted and then cleaved to generate gonadoliberin-1 and GnRH-associated peptide 1. Gonadoliberin-1 stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Mutations in this gene are associated with hypogonadotropic hypogonadism. [provided by RefSeq, Nov 2015]

Chromosome

8

Cytoband

p21.2

Chromosome location (bp)

25419260 - 25424654

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000147437 (version 83.38)

Entrez gene

2796

UniProt

P01148 (UniProt - Evidence at protein level)

neXtProt

NX_P01148

Antibodypedia

GNRH1 antibodies

PROTEIN BROWSER

GNRH1-001
GNRH1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GNRH1-001
ENSP00000276414
ENST00000276414
P01148 [Direct mapping]
Progonadoliberin-1 Gonadoliberin-1 GnRH-associated peptide 1
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Show all
GO:0000003 [reproduction]
GO:0005179 [hormone activity]
GO:0005183 [gonadotropin hormone-releasing hormone activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005739 [mitochondrion]
GO:0005798 [Golgi-associated vesicle]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0007275 [multicellular organismal development]
GO:0007565 [female pregnancy]
GO:0007568 [aging]
GO:0008285 [negative regulation of cell proliferation]
GO:0010468 [regulation of gene expression]
GO:0014070 [response to organic cyclic compound]
GO:0030238 [male sex determination]
GO:0030425 [dendrite]
GO:0031530 [gonadotropin-releasing hormone receptor binding]
GO:0031960 [response to corticosteroid]
GO:0032496 [response to lipopolysaccharide]
GO:0033087 [negative regulation of immature T cell proliferation]
GO:0033574 [response to testosterone]
GO:0034695 [response to prostaglandin E]
GO:0035864 [response to potassium ion]
GO:0042698 [ovulation cycle]
GO:0043005 [neuron projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0043204 [perikaryon]
GO:0043434 [response to peptide hormone]
GO:0043679 [axon terminus]
GO:0044849 [estrous cycle]
GO:0045471 [response to ethanol]
GO:0046883 [regulation of hormone secretion]
GO:0048545 [response to steroid hormone]
GO:0098556 [cytoplasmic side of rough endoplasmic reticulum membrane]
GO:1990008 [neurosecretory vesicle]
GO:1990637 [response to prolactin]
GO:2000354 [regulation of ovarian follicle development]
GO:2001223 [negative regulation of neuron migration]
Show all
92 aa
10.4 kDa
Yes 0
GNRH1-002
ENSP00000391280
ENST00000421054
P01148 [Direct mapping]
Progonadoliberin-1 Gonadoliberin-1 GnRH-associated peptide 1
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Show all
GO:0000003 [reproduction]
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0007275 [multicellular organismal development]
GO:0008285 [negative regulation of cell proliferation]
GO:0031530 [gonadotropin-releasing hormone receptor binding]
GO:0046883 [regulation of hormone secretion]
Show all
92 aa
10.4 kDa
Yes 0

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