Expression of DPYS in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Dihydropyrimidinase

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA024785

GENE INFORMATION
Gene name	DPYS (HGNC Symbol)
Synonyms	DHPase
Description	Dihydropyrimidinase (HGNC Symbol)
Entrez gene summary	Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	q22.3
Chromosome location (bp)	104330324 - 104467053
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000147647 (version 83.38)
Entrez gene	1807
UniProt	Q14117 (UniProt - Evidence at protein level)
neXtProt	NX_Q14117
Antibodypedia	DPYS antibodies

PROTEIN BROWSER

DPYS-001	DPYS-005	DPYS-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DPYS-001 ENSP00000276651 ENST00000351513	Q14117 [Direct mapping] Dihydropyrimidinase Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002058 [uracil binding] GO:0002059 [thymine binding] GO:0004157 [dihydropyrimidinase activity] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006206 [pyrimidine nucleobase metabolic process] GO:0006208 [pyrimidine nucleobase catabolic process] GO:0006210 [thymine catabolic process] GO:0006212 [uracil catabolic process] GO:0008270 [zinc ion binding] GO:0016597 [amino acid binding] GO:0016787 [hydrolase activity] GO:0016810 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds] GO:0019482 [beta-alanine metabolic process] GO:0019860 [uracil metabolic process] GO:0044281 [small molecule metabolic process] GO:0046135 [pyrimidine nucleoside catabolic process] GO:0051219 [phosphoprotein binding] GO:0051260 [protein homooligomerization] GO:0051289 [protein homotetramerization] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	519 aa 56.6 kDa	No	0
DPYS-005 ENSP00000430246 ENST00000521573	E5RG28 [Direct mapping] Dihydropyrimidinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016810 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds] Show all	150 aa 16.2 kDa	No	0
DPYS-007 ENSP00000436654 ENST00000533874	H0YEV7 [Direct mapping] Dihydropyrimidinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016810 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds] Show all	54 aa 6.4 kDa	No	0