Tissue expression of UHRF2 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	UHRF2
Gene description	Ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	UHRF2 (HGNC Symbol)
Synonyms	MGC33463, NIRF, RNF107, TDRD23, URF2
Description	Ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase (HGNC Symbol)
Entrez gene summary	This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding. [provided by RefSeq, Feb 2012]
Chromosome	9
Cytoband	p24.1
Chromosome location (bp)	6413151 - 6507054
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000147854 (version 83.38)
Entrez gene	115426
UniProt	Q96PU4 (UniProt - Evidence at protein level)
neXtProt	NX_Q96PU4
Antibodypedia	UHRF2 antibodies

PROTEIN BROWSER

UHRF2-002	UHRF2-003	UHRF2-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UHRF2-002 ENSP00000370778 ENST00000381373	B1AL33 [Direct mapping] E3 ubiquitin-protein ligase UHRF2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005720 [nuclear heterochromatin] GO:0010216 [maintenance of DNA methylation] GO:0090308 [regulation of methylation-dependent chromatin silencing] Show all	136 aa 15.3 kDa	No	0
UHRF2-003 ENSP00000276893 ENST00000276893	Q96PU4 [Direct mapping] E3 ubiquitin-protein ligase UHRF2 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005720 [nuclear heterochromatin] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0007049 [cell cycle] GO:0008270 [zinc ion binding] GO:0008283 [cell proliferation] GO:0010216 [maintenance of DNA methylation] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0030154 [cell differentiation] GO:0042393 [histone binding] GO:0051726 [regulation of cell cycle] GO:0051865 [protein autoubiquitination] GO:0061630 [ubiquitin protein ligase activity] GO:0071158 [positive regulation of cell cycle arrest] GO:0090308 [regulation of methylation-dependent chromatin silencing] Show all	802 aa 90 kDa	No	0
UHRF2-004 ENSP00000399217 ENST00000450508	A0A0A0MSQ3 [Direct mapping] E3 ubiquitin-protein ligase UHRF2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005720 [nuclear heterochromatin] GO:0010216 [maintenance of DNA methylation] GO:0090308 [regulation of methylation-dependent chromatin silencing] Show all	112 aa 12.7 kDa	No	0