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CDKN2B

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GENERAL INFORMATION

Gene name

 CDKN2B

Gene description

 Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoplasm.

RNA cell category

 Cell line enhanced (SiHa, HaCaT)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA052838
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SiHa, HaCaT)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoplasm.

Main location

 Nucleoplasm (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA052838 HEK 293 Nucleoplasm
HPA052838 HeLa Nucleoplasm
HPA052838 U-2 OS Nucleoplasm

GENE INFORMATION

Gene name

 CDKN2B (HGNC Symbol)

Synonyms

 CDK4I, INK4B, MTS2, P15, p15INK4b, TP15

Description

 Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (HGNC Symbol)

Entrez gene summary

 This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 p21.3

Chromosome location (bp)

 22002903 - 22009363

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000147883 (version 83.38)

Entrez gene

 1030

UniProt

 P42772 (UniProt - Evidence at protein level)

neXtProt

 NX_P42772

Antibodypedia

 CDKN2B antibodies

PROTEIN BROWSER
CDKN2B-001
CDKN2B-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDKN2B-001
ENSP00000276925
ENST00000276925
P42772 [Direct mapping]
Cyclin-dependent kinase 4 inhibitor B
K7PPU3 [Target identity:100%; Query identity:100%]
Cyclin-dependent kinase inhibitor 2B; Cyclin-dependent kinase inhibitor 2B (P15, inhibits CDK4), isoform CRA_b; P15
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Predicted intracellular proteins
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GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0004861 [cyclin-dependent protein serine/threonine kinase inhibitor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007050 [cell cycle arrest]
GO:0007093 [mitotic cell cycle checkpoint]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008285 [negative regulation of cell proliferation]
GO:0010467 [gene expression]
GO:0019901 [protein kinase binding]
GO:0030219 [megakaryocyte differentiation]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0031668 [cellular response to extracellular stimulus]
GO:0031670 [cellular response to nutrient]
GO:0042326 [negative regulation of phosphorylation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048536 [spleen development]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0071901 [negative regulation of protein serine/threonine kinase activity]
GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]
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 138 aa
14.7 kDa 		No 0
CDKN2B-002
ENSP00000369487
ENST00000380142
P42772 [Direct mapping]
Cyclin-dependent kinase 4 inhibitor B
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Predicted intracellular proteins
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0004861 [cyclin-dependent protein serine/threonine kinase inhibitor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007050 [cell cycle arrest]
GO:0007093 [mitotic cell cycle checkpoint]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008285 [negative regulation of cell proliferation]
GO:0010467 [gene expression]
GO:0019901 [protein kinase binding]
GO:0030219 [megakaryocyte differentiation]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0031668 [cellular response to extracellular stimulus]
GO:0031670 [cellular response to nutrient]
GO:0042326 [negative regulation of phosphorylation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0071901 [negative regulation of protein serine/threonine kinase activity]
Show all
 78 aa
8.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.