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Several renal cancers displayed moderate to strong cytoplasmic staining while fractions of cases in several other malignancies including liver and endometrial cancers showed moderate staining. Malignant cells in general were negative.
GENE INFORMATION
Gene name
FBXO10 (HGNC Symbol)
Synonyms
FBX10
Description
F-box protein 10 (HGNC Symbol)
Entrez gene summary
Members of the F-box protein family, such as FBXO10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]