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Most cancer tissues howed weak to moderate cytoplasmic immunoreactivity. Strong positivity was observed i gliomas and a few testicular cancers.
GENE INFORMATION
Gene name
NTRK2 (HGNC Symbol)
Synonyms
TRKB
Description
Neurotrophic tyrosine kinase, receptor, type 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]