Cell atlas - STOM - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

STOM

TISSUE

premium

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	STOM
Gene description	Stomatin
Protein class	Plasma proteins Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Cell line enhanced (hTCEpi)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA010961 , HPA011419
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (hTCEpi) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA010961	A-431	Cytosol
	HPA010961	U-2 OS	Cytosol
	HPA010961	U-251 MG	Cytosol
	HPA011419	A-431	Cytosol
	HPA011419	U-2 OS	Cytosol
	HPA011419	U-251 MG	Cytosol

GENE INFORMATION
Gene name	STOM (HGNC Symbol)
Synonyms	BND7, EPB7, EPB72
Description	Stomatin (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a highly conserved family of integral membrane proteins. The encoded protein localizes to the cell membrane of red blood cells and other cell types, where it may regulate ion channels and transporters. Loss of localization of the encoded protein is associated with hereditary stomatocytosis, a form of hemolytic anemia. There is a pseudogene for this gene on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Chromosome	9
Cytoband	q33.2
Chromosome location (bp)	121338988 - 121370304
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000148175 (version 83.38)
Entrez gene	2040
UniProt	P27105 (UniProt - Evidence at protein level)
neXtProt	NX_P27105
Antibodypedia	STOM antibodies

PROTEIN BROWSER

STOM-001	STOM-002	STOM-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
STOM-001 ENSP00000286713 ENST00000286713	P27105 [Direct mapping] Erythrocyte band 7 integral membrane protein A0A024R882 [Target identity:100%; Query identity:100%] Stomatin, isoform CRA_a Show all	Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002230 [positive regulation of defense response to virus by host] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005856 [cytoskeleton] GO:0005887 [integral component of plasma membrane] GO:0016020 [membrane] GO:0031982 [vesicle] GO:0034765 [regulation of ion transmembrane transport] GO:0042470 [melanosome] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0044829 [positive regulation by host of viral genome replication] GO:0045121 [membrane raft] GO:0048471 [perinuclear region of cytoplasm] GO:0048524 [positive regulation of viral process] GO:0051260 [protein homooligomerization] GO:0070062 [extracellular exosome] GO:0070063 [RNA polymerase binding] GO:0072562 [blood microparticle] GO:0090314 [positive regulation of protein targeting to membrane] GO:0098779 [mitophagy in response to mitochondrial depolarization] GO:1901585 [regulation of acid-sensing ion channel activity] Show all	288 aa 31.7 kDa	No	1
STOM-002 ENSP00000339607 ENST00000347359	P27105 [Direct mapping] Erythrocyte band 7 integral membrane protein Show all	Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002230 [positive regulation of defense response to virus by host] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005856 [cytoskeleton] GO:0005887 [integral component of plasma membrane] GO:0016020 [membrane] GO:0031982 [vesicle] GO:0042470 [melanosome] GO:0045121 [membrane raft] GO:0051260 [protein homooligomerization] GO:0070062 [extracellular exosome] GO:0070063 [RNA polymerase binding] GO:0072562 [blood microparticle] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	123 aa 13.5 kDa	No	1
STOM-201 ENSP00000445764 ENST00000538954	F8VSL7 [Direct mapping] Erythrocyte band 7 integral membrane protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	168 aa 18.7 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.