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LCN2

CANCER ATLAS

Gene description

 Lipocalin 2

Protein class

 Candidate cardiovascular disease genes, Plasma proteins, Predicted secreted proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA002695
CAB016549
CAB016550

GENE INFORMATION

Gene name

 LCN2 (HGNC Symbol)

Synonyms

 24p3, NGAL

Description

 Lipocalin 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that belongs to the lipocalin family. Members of this family transport small hydrophobic molecules such as lipids, steroid hormones and retinoids. The protein encoded by this gene is a neutrophil gelatinase-associated lipocalin and plays a role in innate immunity by limiting bacterial growth as a result of sequestering iron-containing siderophores. The presence of this protein in blood and urine is an early biomarker of acute kidney injury. This protein is thought to be be involved in multiple cellular processes, including maintenance of skin homeostasis, and suppression of invasiveness and metastasis. Mice lacking this gene are more susceptible to bacterial infection than wild type mice. [provided by RefSeq, Sep 2015]

Chromosome

 9

Cytoband

 q34.11

Chromosome location (bp)

 128149071 - 128153455

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000148346 (version 83.38)

Entrez gene

 3934

UniProt

 P80188 (UniProt - Evidence at protein level)

neXtProt

 NX_P80188

Antibodypedia

 LCN2 antibodies

PROTEIN BROWSER
LCN2-001
LCN2-002
LCN2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LCN2-001
ENSP00000277480
ENST00000277480
P80188 [Direct mapping]
Neutrophil gelatinase-associated lipocalin
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Candidate cardiovascular disease genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005506 [iron ion binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006811 [ion transport]
GO:0006879 [cellular iron ion homeostasis]
GO:0015891 [siderophore transport]
GO:0036094 [small molecule binding]
GO:0045087 [innate immune response]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
Show all
 198 aa
22.6 kDa 		Yes 0
LCN2-002
ENSP00000362089
ENST00000372998
X6R8F3 [Direct mapping]
Neutrophil gelatinase-associated lipocalin
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005576 [extracellular region]
GO:0006810 [transport]
GO:0036094 [small molecule binding]
Show all
 200 aa
22.8 kDa 		Yes 0
LCN2-003
ENSP00000362108
ENST00000373017
P80188 [Direct mapping]
Neutrophil gelatinase-associated lipocalin
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Candidate cardiovascular disease genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020 [protease binding]
GO:0005215 [transporter activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005829 [cytosol]
GO:0006811 [ion transport]
GO:0006879 [cellular iron ion homeostasis]
GO:0006979 [response to oxidative stress]
GO:0009615 [response to virus]
GO:0009617 [response to bacterium]
GO:0009635 [response to herbicide]
GO:0010046 [response to mycotoxin]
GO:0010628 [positive regulation of gene expression]
GO:0015891 [siderophore transport]
GO:0031346 [positive regulation of cell projection organization]
GO:0031667 [response to nutrient levels]
GO:0031669 [cellular response to nutrient levels]
GO:0036094 [small molecule binding]
GO:0042493 [response to drug]
GO:0042803 [protein homodimerization activity]
GO:0045087 [innate immune response]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0070207 [protein homotrimerization]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
Show all
 198 aa
22.6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.