Expression of INPP5E in cancer - Summary

CANCER ATLAS

Gene description

Inositol polyphosphate-5-phosphatase E

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Skin cancer

STAINING SUMMARY

HPA065758

GENE INFORMATION
Gene name	INPP5E (HGNC Symbol)
Synonyms	CORS1, JBTS1, PPI5PIV
Description	Inositol polyphosphate-5-phosphatase E (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly.[provided by RefSeq, Feb 2011]
Chromosome	9
Cytoband	q34.3
Chromosome location (bp)	136428619 - 136439822
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000148384 (version 83.38)
Entrez gene	56623
UniProt	Q9NRR6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NRR6
Antibodypedia	INPP5E antibodies

PROTEIN BROWSER

INPP5E-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
INPP5E-001 ENSP00000360777 ENST00000371712	Q9NRR6 [Direct mapping] 72 kDa inositol polyphosphate 5-phosphatase Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0001726 [ruffle] GO:0004439 [phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity] GO:0004445 [inositol-polyphosphate 5-phosphatase activity] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005930 [axoneme] GO:0006644 [phospholipid metabolic process] GO:0006661 [phosphatidylinositol biosynthetic process] GO:0006996 [organelle organization] GO:0008150 [biological_process] GO:0010976 [positive regulation of neuron projection development] GO:0032580 [Golgi cisterna membrane] GO:0044281 [small molecule metabolic process] GO:0046488 [phosphatidylinositol metabolic process] GO:0046855 [inositol phosphate dephosphorylation] GO:0046856 [phosphatidylinositol dephosphorylation] GO:0072372 [primary cilium] Show all	644 aa 70.2 kDa	No	0