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Moderate cytoplasmic and nuclear staining in all cancer tissues. Colorectal cancers and a few cases of ovarian, pancreatic and gastric cancers showed strong staining.
Weak to moderate nuclear and cytoplasmic staining in all cancers. A few cases of stomach, pancreatic, breast and ovarian cancers displayed strong positivity.
GENE INFORMATION
Gene name
NOTCH1 (HGNC Symbol)
Synonyms
TAN1
Description
Notch 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. [provided by RefSeq, Jul 2008]