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PDSS1

GENERAL INFORMATION

Gene name

 PDSS1

Gene description

 Prenyl (decaprenyl) diphosphate synthase, subunit 1

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA038032
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PDSS1 (HGNC Symbol)

Synonyms

 COQ1, TPRT, TPT

Description

 Prenyl (decaprenyl) diphosphate synthase, subunit 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an enzyme that elongates the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis. The protein may be peripherally associated with the inner mitochondrial membrane, though no transit peptide has been definitively identified to date. Defects in this gene are a cause of coenzyme Q10 deficiency. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 p12.1

Chromosome location (bp)

 26697659 - 26746798

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000148459 (version 83.38)

Entrez gene

 23590

UniProt

 Q5T2R2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q5T2R2

Antibodypedia

 PDSS1 antibodies

PROTEIN BROWSER
PDSS1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PDSS1-001
ENSP00000365388
ENST00000376215
Q5T2R2 [Direct mapping]
Decaprenyl-diphosphate synthase subunit 1
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Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000010 [trans-hexaprenyltranstransferase activity]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006744 [ubiquinone biosynthetic process]
GO:0008299 [isoprenoid biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0050347 [trans-octaprenyltranstransferase activity]
GO:0051290 [protein heterotetramerization]
GO:1990234 [transferase complex]
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 415 aa
46.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.