Tissue expression of SLC39A12 - Summary

GENERAL INFORMATION
Gene name	SLC39A12
Gene description	Solute carrier family 39 (zinc transporter), member 12
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (cerebral cortex)
GTEx:	Group enriched (cerebral cortex, hippocampus, caudate, hypothalamus)
FANTOM5:	Tissue enhanced (retina, hippocampus, brain)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (cerebral cortex, hippocampus, caudate, hypothalamus)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (retina, hippocampus, brain)

GENE INFORMATION
Gene name	SLC39A12 (HGNC Symbol)
Synonyms	FLJ30499
Description	Solute carrier family 39 (zinc transporter), member 12 (HGNC Symbol)
Entrez gene summary	Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A12 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Aug 2008]
Chromosome	10
Cytoband	p12.33
Chromosome location (bp)	17951839 - 18043292
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000148482 (version 83.38)
Entrez gene	221074
UniProt	Q504Y0 (UniProt - Evidence at transcript level)
neXtProt	NX_Q504Y0
Antibodypedia	SLC39A12 antibodies

PROTEIN BROWSER

SLC39A12-001	SLC39A12-002	SLC39A12-201	SLC39A12-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC39A12-001 ENSP00000366588 ENST00000377371	Q504Y0 [Direct mapping] Zinc transporter ZIP12 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030001 [metal ion transport] GO:0046873 [metal ion transmembrane transporter activity] GO:0055085 [transmembrane transport] GO:1903561 [extracellular vesicle] Show all	690 aa 76.5 kDa	Yes	7
SLC39A12-002 ENSP00000366591 ENST00000377374	Q504Y0 [Direct mapping] Zinc transporter ZIP12 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030001 [metal ion transport] GO:0046873 [metal ion transmembrane transporter activity] GO:0055085 [transmembrane transport] GO:1903561 [extracellular vesicle] Show all	654 aa 72.9 kDa	Yes	7
SLC39A12-201 ENSP00000366586 ENST00000377369	Q504Y0 [Direct mapping] Zinc transporter ZIP12 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005385 [zinc ion transmembrane transporter activity] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0010975 [regulation of neuron projection development] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030001 [metal ion transport] GO:0031113 [regulation of microtubule polymerization] GO:0046873 [metal ion transmembrane transporter activity] GO:0048471 [perinuclear region of cytoplasm] GO:0055085 [transmembrane transport] GO:0071578 [zinc II ion transmembrane import] GO:1903561 [extracellular vesicle] Show all	691 aa 76.7 kDa	Yes	7
SLC39A12-202 ENSP00000440445 ENST00000539911	Q504Y0 [Direct mapping] Zinc transporter ZIP12 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030001 [metal ion transport] GO:0046873 [metal ion transmembrane transporter activity] GO:0055085 [transmembrane transport] GO:1903561 [extracellular vesicle] Show all	557 aa 61.6 kDa	No	7