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A1CF

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GENERAL INFORMATION

Gene name

 A1CF

Gene description

 APOBEC1 complementation factor

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoplasm.

RNA cell category

 Group enriched (Hep G2, CACO-2)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA044079
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (Hep G2, CACO-2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoplasm.

Main location

 Nucleoplasm (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA044079 CACO-2 Nucleoplasm
HPA044079 Hep G2 Nucleoplasm
HPA044079 U-2 OS No staining    

GENE INFORMATION

Gene name

 A1CF (HGNC Symbol)

Synonyms

 ACF, ACF64, ACF65, APOBEC1CF, ASP

Description

 APOBEC1 complementation factor (HGNC Symbol)

Entrez gene summary

 Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Chromosome

 10

Cytoband

 q11.23

Chromosome location (bp)

 50799409 - 50885675

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000148584 (version 83.38)

Entrez gene

 29974

UniProt

 Q9NQ94 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NQ94

Antibodypedia

 A1CF antibodies

PROTEIN BROWSER
A1CF-001
A1CF-002
A1CF-003
A1CF-004
A1CF-006
A1CF-201
A1CF-202
A1CF-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
A1CF-001
ENSP00000363113
ENST00000374001
Q9NQ94 [Direct mapping]
APOBEC1 complementation factor
A0A024QZJ5 [Target identity:100%; Query identity:100%]
Apobec-1 complementation factor, isoform CRA_b
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003727 [single-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0006397 [mRNA processing]
GO:0010467 [gene expression]
GO:0016554 [cytidine to uridine editing]
GO:0016556 [mRNA modification]
GO:0030895 [apolipoprotein B mRNA editing enzyme complex]
GO:0050821 [protein stabilization]
Show all
 586 aa
64.3 kDa 		No 0
A1CF-002
ENSP00000363105
ENST00000373993
Q9NQ94 [Direct mapping]
APOBEC1 complementation factor
A0A024QZM7 [Target identity:100%; Query identity:100%]
Apobec-1 complementation factor, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003727 [single-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0006397 [mRNA processing]
GO:0010467 [gene expression]
GO:0016554 [cytidine to uridine editing]
GO:0016556 [mRNA modification]
GO:0030895 [apolipoprotein B mRNA editing enzyme complex]
GO:0050821 [protein stabilization]
Show all
 594 aa
65.2 kDa 		No 0
A1CF-003
ENSP00000397953
ENST00000414883
Q5T0W7 [Direct mapping]
APOBEC1 complementation factor
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
Show all
 201 aa
22.5 kDa 		No 0
A1CF-004
ENSP00000363109
ENST00000373997
Q9NQ94 [Direct mapping]
APOBEC1 complementation factor
A0A024QZJ5 [Target identity:100%; Query identity:100%]
Apobec-1 complementation factor, isoform CRA_b
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003727 [single-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0006397 [mRNA processing]
GO:0010467 [gene expression]
GO:0016554 [cytidine to uridine editing]
GO:0016556 [mRNA modification]
GO:0030895 [apolipoprotein B mRNA editing enzyme complex]
GO:0050821 [protein stabilization]
Show all
 586 aa
64.3 kDa 		No 0
A1CF-006
ENSP00000363107
ENST00000373995
Q9NQ94 [Direct mapping]
APOBEC1 complementation factor
A0A024QZI9 [Target identity:100%; Query identity:100%]
Apobec-1 complementation factor, isoform CRA_c
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003727 [single-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0006397 [mRNA processing]
GO:0010467 [gene expression]
GO:0016554 [cytidine to uridine editing]
GO:0016556 [mRNA modification]
GO:0030895 [apolipoprotein B mRNA editing enzyme complex]
GO:0050821 [protein stabilization]
Show all
 594 aa
65 kDa 		No 0
A1CF-201
ENSP00000282641
ENST00000282641
Q9NQ94 [Direct mapping]
APOBEC1 complementation factor
A0A024QZJ5 [Target identity:100%; Query identity:100%]
Apobec-1 complementation factor, isoform CRA_b
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003727 [single-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0006397 [mRNA processing]
GO:0010467 [gene expression]
GO:0016554 [cytidine to uridine editing]
GO:0016556 [mRNA modification]
GO:0030895 [apolipoprotein B mRNA editing enzyme complex]
GO:0050821 [protein stabilization]
Show all
 586 aa
64.3 kDa 		No 0
A1CF-202
ENSP00000378868
ENST00000395489
F8W9F8 [Direct mapping]
APOBEC1 complementation factor
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0010609 [mRNA localization resulting in posttranscriptional regulation of gene expression]
GO:0016556 [mRNA modification]
Show all
 602 aa
66 kDa 		No 0
A1CF-203
ENSP00000378873
ENST00000395495
Q9NQ94 [Direct mapping]
APOBEC1 complementation factor
A0A024QZI9 [Target identity:100%; Query identity:100%]
Apobec-1 complementation factor, isoform CRA_c
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003727 [single-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0006397 [mRNA processing]
GO:0010467 [gene expression]
GO:0016554 [cytidine to uridine editing]
GO:0016556 [mRNA modification]
GO:0030895 [apolipoprotein B mRNA editing enzyme complex]
GO:0050821 [protein stabilization]
Show all
 594 aa
65 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.