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Most tumour cells showed moderate nuclear and cytoplasmic immunoreactivity. Hepatocellular carcinomas along with several cases of colorectal and breast cancers were strongly stained. Several cases of renal cancers were weakly stained or negative.
GENE INFORMATION
Gene name
POLR3A (HGNC Symbol)
Synonyms
hRPC155, RPC1, RPC155
Description
Polymerase (RNA) III (DNA directed) polypeptide A, 155kDa (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is the catalytic component of RNA polymerase III, which synthesizes small RNAs. The encoded protein also acts as a sensor to detect foreign DNA and trigger an innate immune response. [provided by RefSeq, Aug 2011]
O14802 [Direct mapping] DNA-directed RNA polymerase III subunit RPC1
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Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins RNA polymerase related proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001056 [RNA polymerase III activity] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003899 [DNA-directed RNA polymerase activity] GO:0005654 [nucleoplasm] GO:0005666 [DNA-directed RNA polymerase III complex] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006383 [transcription from RNA polymerase III promoter] GO:0006385 [transcription elongation from RNA polymerase III promoter] GO:0006386 [termination of RNA polymerase III transcription] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0032481 [positive regulation of type I interferon production] GO:0032728 [positive regulation of interferon-beta production] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] GO:0051607 [defense response to virus] GO:1903146 [regulation of mitophagy] GO:1903955 [positive regulation of protein targeting to mitochondrion]
