Tissue expression of HERC4 - Summary - The Human Protein Atlas

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HERC4

TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	HERC4
Gene description	HECT and RLD domain containing E3 ubiquitin protein ligase 4
Protein class	Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Pending retesting.
Reliability score	Uncertain based on 1 antibody. HPA045453
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	HERC4 (HGNC Symbol)
Synonyms	DKFZP564G092, KIAA1593
Description	HECT and RLD domain containing E3 ubiquitin protein ligase 4 (HGNC Symbol)
Entrez gene summary	HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008]
Chromosome	10
Cytoband	q21.3
Chromosome location (bp)	67921899 - 68075348
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000148634 (version 83.38)
Entrez gene	26091
UniProt	Q5GLZ8 (UniProt - Evidence at protein level)
neXtProt	NX_Q5GLZ8
Antibodypedia	HERC4 antibodies

PROTEIN BROWSER

HERC4-001	HERC4-002	HERC4-006	HERC4-008	HERC4-009	HERC4-013	HERC4-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HERC4-001 ENSP00000362804 ENST00000373700	Q5GLZ8 [Direct mapping] Probable E3 ubiquitin-protein ligase HERC4 A0A024QZN8 [Target identity:100%; Query identity:100%] Hect domain and RLD 4, isoform CRA_b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007283 [spermatogenesis] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0030154 [cell differentiation] GO:0061630 [ubiquitin protein ligase activity] Show all	1049 aa 117.7 kDa	No	1
HERC4-002 ENSP00000277817 ENST00000277817	Q5GLZ8 [Direct mapping] Probable E3 ubiquitin-protein ligase HERC4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007283 [spermatogenesis] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0030154 [cell differentiation] GO:0061630 [ubiquitin protein ligase activity] Show all	947 aa 106.7 kDa	No	1
HERC4-006 ENSP00000422383 ENST00000492996	Q5GLZ8 [Direct mapping] Probable E3 ubiquitin-protein ligase HERC4 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007283 [spermatogenesis] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0030154 [cell differentiation] GO:0061630 [ubiquitin protein ligase activity] Show all	110 aa 12 kDa	No	0
HERC4-008 ENSP00000416504 ENST00000412272	Q5GLZ8 [Direct mapping] Probable E3 ubiquitin-protein ligase HERC4 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007283 [spermatogenesis] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0030154 [cell differentiation] GO:0061630 [ubiquitin protein ligase activity] Show all	979 aa 109.6 kDa	No	0
HERC4-009 ENSP00000378624 ENST00000395198	Q5GLZ8 [Direct mapping] Probable E3 ubiquitin-protein ligase HERC4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007283 [spermatogenesis] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0030154 [cell differentiation] GO:0061630 [ubiquitin protein ligase activity] Show all	1057 aa 118.6 kDa	No	1
HERC4-013 ENSP00000426563 ENST00000506515	D6RFK9 [Direct mapping] Probable E3 ubiquitin-protein ligase HERC4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		29 aa 3.1 kDa	No	0
HERC4-015 ENSP00000427191 ENST00000513996	D6RCL5 [Direct mapping] Probable E3 ubiquitin-protein ligase HERC4 Show all	TMHMM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		240 aa 25.9 kDa	No	0

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The Human Protein Atlas

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