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Most tumour tissues exhibited moderate to strong cytoplasmic and membranous positivity. The majority of prostate and skin cancers were weakly stained or negative.
Tumour tissues exhibited moderate membranous and cytoplasmic immunoreactivity. Fractions of colorectal and endometrial cancers showed strong staining. Most hepatocellular, prostate, lung and renal cancers were weakly stained or negative.
GENE INFORMATION
Gene name
ADD3 (HGNC Symbol)
Synonyms
ADDL
Description
Adducin 3 (gamma) (HGNC Symbol)
Entrez gene summary
Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described. The functions of the different isoforms are not known. [provided by RefSeq, Jul 2008]
