Expression of VAX1 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Ventral anterior homeobox 1

Protein class

Disease related genes, Predicted intracellular proteins, Transcription factors

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA028946

GENE INFORMATION
Gene name	VAX1
Synonyms
Description	Ventral anterior homeobox 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a homeo-domain containing protein from a class of homeobox transcription factors which are conserved in vertebrates. Genes of this family are involved in the regulation of body development and morphogenesis. The most conserved genes, called HOX genes are found in special gene clusters. This gene belongs to the VAX subfamily and lies in the vicinity of the EMX homeobox gene family. Another member of VAX family is located on chromosome 2. The encoded protein may play an important role in the development of anterior ventral forebrain and visual system. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	10
Cytoband	q25.3
Chromosome location (bp)	117128521 - 117138301
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000148704 (version 83.38)
Entrez gene	11023
UniProt	Q5SQQ9 (UniProt - Evidence at protein level)
neXtProt	NX_Q5SQQ9
Antibodypedia	VAX1 antibodies

PROTEIN BROWSER

VAX1-001	VAX1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
VAX1-001 ENSP00000358207 ENST00000369206	Q5SQQ9 [Direct mapping] Ventral anterior homeobox 1 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Disease related genes Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001162 [RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0001764 [neuron migration] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007399 [nervous system development] GO:0007406 [negative regulation of neuroblast proliferation] GO:0007411 [axon guidance] GO:0007417 [central nervous system development] GO:0007420 [brain development] GO:0030154 [cell differentiation] GO:0031490 [chromatin DNA binding] GO:0035914 [skeletal muscle cell differentiation] GO:0043010 [camera-type eye development] GO:0043565 [sequence-specific DNA binding] GO:0060021 [palate development] Show all	334 aa 34.7 kDa	No	0
VAX1-002 ENSP00000277905 ENST00000277905	Q5SQQ9 [Direct mapping] Ventral anterior homeobox 1 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Disease related genes Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] Show all	186 aa 21 kDa	No	0