Cell atlas - DNAJB12 - The Human Protein Atlas

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DNAJB12

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum

Human cell
	Endoplasmic Reticulum

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GENERAL INFORMATION
Gene name	DNAJB12
Gene description	DnaJ (Hsp40) homolog, subfamily B, member 12
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the endoplasmic reticulum.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (supported)
Mouse	Localized to the Endoplasmic reticulum in mouse cells.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA010642
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the endoplasmic reticulum.

Main location

Endoplasmic reticulum (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA010642	A-431	Endoplasmic reticulum
	HPA010642	U-2 OS	Endoplasmic reticulum
	HPA010642	U-251 MG	Endoplasmic reticulum

MOUSE CELLS

Main location

Endoplasmic reticulum

Mouse gene

ENSMUSG00000020109 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA010642	NIH 3T3	Endoplasmic reticulum

GENE INFORMATION
Gene name	DNAJB12 (HGNC Symbol)
Synonyms	DJ10, FLJ20027
Description	DnaJ (Hsp40) homolog, subfamily B, member 12 (HGNC Symbol)
Entrez gene summary	DNAJB12 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus; a glycine/phenylalanine (G/F)-rich region; and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain (Ohtsuka and Hata, 2000 [PubMed 11147971]).[supplied by OMIM, Mar 2008]
Chromosome	10
Cytoband	q22.1
Chromosome location (bp)	72332830 - 72355230
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000148719 (version 83.38)
Entrez gene	54788
UniProt	Q9NXW2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NXW2
Antibodypedia	DNAJB12 antibodies

PROTEIN BROWSER

DNAJB12-001	DNAJB12-002	DNAJB12-003	DNAJB12-201	DNAJB12-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DNAJB12-001 ENSP00000403313 ENST00000444643	Q9NXW2 [Direct mapping] DnaJ homolog subfamily B member 12 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	375 aa 41.9 kDa	No	1
DNAJB12-002 ENSP00000476941 ENST00000463786	V9GYN7 [Direct mapping] DnaJ homolog subfamily B member 12 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	276 aa 31.1 kDa	No	1
DNAJB12-003 ENSP00000476453 ENST00000461919	V9GY70 [Direct mapping] DnaJ homolog subfamily B member 12 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		172 aa 19.8 kDa	No	1
DNAJB12-201 ENSP00000345575 ENST00000338820	J3KPS0 [Direct mapping] DnaJ (Hsp40) homolog, subfamily B, member 12, isoform CRA_c; DnaJ homolog subfamily B member 12 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		409 aa 45.5 kDa	No	1
DNAJB12-202 ENSP00000378363 ENST00000394903	J3KPS0 [Direct mapping] DnaJ (Hsp40) homolog, subfamily B, member 12, isoform CRA_c; DnaJ homolog subfamily B member 12 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		409 aa 45.5 kDa	No	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.