Cell atlas - EIF4EBP2 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

EIF4EBP2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria
	Nucleoplasm

Human cell
	Mitochondria
	Nucleoplasm

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	EIF4EBP2
Gene description	Eukaryotic translation initiation factor 4E binding protein 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the mitochondria & nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Mitochondria (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA061665
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the mitochondria & nucleoplasm.

Main location

Nucleoplasm (approved), Mitochondria (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA061665	A-431	Nucleoplasm
	HPA061665	A-431	Mitochondria
	HPA061665	CACO-2	Nucleoplasm
	HPA061665	CACO-2	Mitochondria
	HPA061665	U-2 OS	Nucleoplasm
	HPA061665	U-2 OS	Mitochondria

GENE INFORMATION
Gene name	EIF4EBP2
Synonyms
Description	Eukaryotic translation initiation factor 4E binding protein 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene products of this family bind eIF4E and inhibit translation initiation. However, insulin and other growth factors can release this inhibition via a phosphorylation-dependent disruption of their binding to eIF4E. Regulation of protein production through these gene products have been implicated in cell proliferation, cell differentiation and viral infection. [provided by RefSeq, Oct 2008]
Chromosome	10
Cytoband	q22.1
Chromosome location (bp)	70404379 - 70428618
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000148730 (version 83.38)
Entrez gene	1979
UniProt	Q13542 (UniProt - Evidence at protein level)
neXtProt	NX_Q13542
Antibodypedia	EIF4EBP2 antibodies

PROTEIN BROWSER

EIF4EBP2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EIF4EBP2-001 ENSP00000362314 ENST00000373218	Q13542 [Direct mapping] Eukaryotic translation initiation factor 4E-binding protein 2 A0A024QZM3 [Target identity:100%; Query identity:100%] Eukaryotic translation initiation factor 4E binding protein 2, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006412 [translation] GO:0007613 [memory] GO:0008190 [eukaryotic initiation factor 4E binding] GO:0008286 [insulin receptor signaling pathway] GO:0019933 [cAMP-mediated signaling] GO:0030371 [translation repressor activity] GO:0031929 [TOR signaling] GO:0035176 [social behavior] GO:0045947 [negative regulation of translational initiation] GO:0048167 [regulation of synaptic plasticity] GO:0050804 [modulation of synaptic transmission] Show all	120 aa 12.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.