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TCF7L2

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GENERAL INFORMATION

Gene name

 TCF7L2

Gene description

 Transcription factor 7-like 2 (T-cell specific, HMG-box)

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 18
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nuclear bodies & nucleoplasm.

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (approved), Nuclear bodies (supported)

Single-cell variation

 Single-cell variation in protein expression observed.

Mouse

 Localized to the Nucleoplasm in mouse cells.

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA038800
SHOW MORE

ASSAYS
RNA expression
Human cells
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nuclear bodies & nucleoplasm.

Main location

 Nucleoplasm (approved), Nuclear bodies (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA038800 A-431 Nucleoplasm
Nuclear bodies
HPA038800 U-2 OS Nucleoplasm
HPA038800 U-251 MG Nucleoplasm
Nuclear bodies Spatial
Cytosol

MOUSE CELLS

Main location

 Nucleoplasm

Mouse gene

 ENSMUSG00000024985 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA038800 NIH 3T3 Nucleoplasm

GENE INFORMATION

Gene name

 TCF7L2 (HGNC Symbol)

Synonyms

 TCF-4, TCF4

Description

 Transcription factor 7-like 2 (T-cell specific, HMG-box) (HGNC Symbol)

Entrez gene summary

 This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]

Chromosome

 10

Cytoband

Chromosome location (bp)

 112950250 - 113167678

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000148737 (version 83.38)

Entrez gene

 6934

UniProt

 Q9NQB0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NQB0

Antibodypedia

 TCF7L2 antibodies

PROTEIN BROWSER
«
TCF7L2-001
TCF7L2-002
TCF7L2-003
TCF7L2-004
TCF7L2-006
TCF7L2-007
TCF7L2-010
TCF7L2-014
TCF7L2-015
TCF7L2-201
TCF7L2-202
TCF7L2-203
TCF7L2-204
TCF7L2-205
TCF7L2-206
TCF7L2-207
TCF7L2-208
TCF7L2-209
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TCF7L2-001
ENSP00000358402
ENST00000369395
Q5VVR7 [Direct mapping]
Transcription factor 7-like 2
Show all
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008013 [beta-catenin binding]
GO:0048699 [generation of neurons]
GO:0060070 [canonical Wnt signaling pathway]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
 317 aa
34.9 kDa 		No 0
TCF7L2-002
ENSP00000345640
ENST00000346198
Q5VVR5 [Direct mapping]
Transcription factor 7-like 2
Show all
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008013 [beta-catenin binding]
GO:0048699 [generation of neurons]
GO:0060070 [canonical Wnt signaling pathway]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
 222 aa
24.9 kDa 		No 0
TCF7L2-003
ENSP00000358404
ENST00000369397
Q9NQB0 [Direct mapping]
Transcription factor 7-like 2
Q6FHW4 [Target identity:100%; Query identity:100%]
TCF7L2 protein; Transcription factor 7-like 2 (T-cell specific, HMG-box), isoform CRA_e
Show all
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001103 [RNA polymerase II repressing transcription factor binding]
GO:0001568 [blood vessel development]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007050 [cell cycle arrest]
GO:0008013 [beta-catenin binding]
GO:0008134 [transcription factor binding]
GO:0008283 [cell proliferation]
GO:0009749 [response to glucose]
GO:0010909 [positive regulation of heparan sulfate proteoglycan biosynthetic process]
GO:0016605 [PML body]
GO:0019901 [protein kinase binding]
GO:0031016 [pancreas development]
GO:0032024 [positive regulation of insulin secretion]
GO:0032092 [positive regulation of protein binding]
GO:0032350 [regulation of hormone metabolic process]
GO:0032993 [protein-DNA complex]
GO:0035257 [nuclear hormone receptor binding]
GO:0042593 [glucose homeostasis]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043565 [sequence-specific DNA binding]
GO:0043570 [maintenance of DNA repeat elements]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044334 [canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition]
GO:0045295 [gamma-catenin binding]
GO:0045444 [fat cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046827 [positive regulation of protein export from nucleus]
GO:0048625 [myoblast fate commitment]
GO:0048660 [regulation of smooth muscle cell proliferation]
GO:0048699 [generation of neurons]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060070 [canonical Wnt signaling pathway]
GO:0070016 [armadillo repeat domain binding]
GO:0070369 [beta-catenin-TCF7L2 complex]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:2000675 [negative regulation of type B pancreatic cell apoptotic process]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
 596 aa
65.3 kDa 		No 0
TCF7L2-004
ENSP00000298692
ENST00000349937
Q5VVR8 [Direct mapping]
Transcription factor 7-like 2
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008013 [beta-catenin binding]
GO:0048699 [generation of neurons]
GO:0060070 [canonical Wnt signaling pathway]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
 288 aa
31.5 kDa 		No 0
TCF7L2-006
ENSP00000358393
ENST00000369386
Q5JRY3 [Direct mapping]
Transcription factor 7-like 2
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0005667 [transcription factor complex]
GO:0016055 [Wnt signaling pathway]
GO:0048699 [generation of neurons]
Show all
 120 aa
14.1 kDa 		No 0
TCF7L2-007
ENSP00000358396
ENST00000369389
Q5JRY4 [Direct mapping]
Transcription factor 7-like 2
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0005667 [transcription factor complex]
GO:0016055 [Wnt signaling pathway]
GO:0048699 [generation of neurons]
Show all
 176 aa
20.2 kDa 		No 0
TCF7L2-010
ENSP00000277945
ENST00000277945
Q5JRY5 [Direct mapping]
Transcription factor 7-like 2
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008013 [beta-catenin binding]
GO:0048699 [generation of neurons]
GO:0060070 [canonical Wnt signaling pathway]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
 207 aa
23.7 kDa 		No 0
TCF7L2-014
ENSP00000487507
ENST00000629706
A0A0D9SGH8 [Direct mapping]
Transcription factor 7-like 2
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008013 [beta-catenin binding]
GO:0048699 [generation of neurons]
GO:0060070 [canonical Wnt signaling pathway]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
 584 aa
64 kDa 		No 0
TCF7L2-015
ENSP00000486891
ENST00000627217
Q9NQB0 [Direct mapping]
Transcription factor 7-like 2
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0001103 [RNA polymerase II repressing transcription factor binding]
GO:0001568 [blood vessel development]
GO:0001678 [cellular glucose homeostasis]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0005977 [glycogen metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007050 [cell cycle arrest]
GO:0008013 [beta-catenin binding]
GO:0008134 [transcription factor binding]
GO:0008283 [cell proliferation]
GO:0009267 [cellular response to starvation]
GO:0009749 [response to glucose]
GO:0009791 [post-embryonic development]
GO:0010867 [positive regulation of triglyceride biosynthetic process]
GO:0010909 [positive regulation of heparan sulfate proteoglycan biosynthetic process]
GO:0014003 [oligodendrocyte development]
GO:0016055 [Wnt signaling pathway]
GO:0016605 [PML body]
GO:0019901 [protein kinase binding]
GO:0021915 [neural tube development]
GO:0021983 [pituitary gland development]
GO:0030282 [bone mineralization]
GO:0030514 [negative regulation of BMP signaling pathway]
GO:0030538 [embryonic genitalia morphogenesis]
GO:0031016 [pancreas development]
GO:0031641 [regulation of myelination]
GO:0032024 [positive regulation of insulin secretion]
GO:0032092 [positive regulation of protein binding]
GO:0032252 [secretory granule localization]
GO:0032350 [regulation of hormone metabolic process]
GO:0032993 [protein-DNA complex]
GO:0035019 [somatic stem cell population maintenance]
GO:0035257 [nuclear hormone receptor binding]
GO:0035264 [multicellular organism growth]
GO:0035411 [catenin import into nucleus]
GO:0035947 [regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter]
GO:0040037 [negative regulation of fibroblast growth factor receptor signaling pathway]
GO:0042475 [odontogenesis of dentin-containing tooth]
GO:0042593 [glucose homeostasis]
GO:0043065 [positive regulation of apoptotic process]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043565 [sequence-specific DNA binding]
GO:0043570 [maintenance of DNA repeat elements]
GO:0043588 [skin development]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044334 [canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition]
GO:0045295 [gamma-catenin binding]
GO:0045444 [fat cell differentiation]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045722 [positive regulation of gluconeogenesis]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046621 [negative regulation of organ growth]
GO:0046827 [positive regulation of protein export from nucleus]
GO:0046889 [positive regulation of lipid biosynthetic process]
GO:0048557 [embryonic digestive tract morphogenesis]
GO:0048619 [embryonic hindgut morphogenesis]
GO:0048625 [myoblast fate commitment]
GO:0048641 [regulation of skeletal muscle tissue development]
GO:0048660 [regulation of smooth muscle cell proliferation]
GO:0048699 [generation of neurons]
GO:0048713 [regulation of oligodendrocyte differentiation]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060325 [face morphogenesis]
GO:0061178 [regulation of insulin secretion involved in cellular response to glucose stimulus]
GO:0070016 [armadillo repeat domain binding]
GO:0070369 [beta-catenin-TCF7L2 complex]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:1901142 [insulin metabolic process]
GO:2000675 [negative regulation of type B pancreatic cell apoptotic process]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
 602 aa
66.1 kDa 		No 0
TCF7L2-201
ENSP00000344823
ENST00000352065
Q9NQB0 [Direct mapping]
Transcription factor 7-like 2
Show all
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001103 [RNA polymerase II repressing transcription factor binding]
GO:0001568 [blood vessel development]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007050 [cell cycle arrest]
GO:0008013 [beta-catenin binding]
GO:0008134 [transcription factor binding]
GO:0008283 [cell proliferation]
GO:0009749 [response to glucose]
GO:0010909 [positive regulation of heparan sulfate proteoglycan biosynthetic process]
GO:0016605 [PML body]
GO:0019901 [protein kinase binding]
GO:0031016 [pancreas development]
GO:0032024 [positive regulation of insulin secretion]
GO:0032092 [positive regulation of protein binding]
GO:0032350 [regulation of hormone metabolic process]
GO:0032993 [protein-DNA complex]
GO:0035257 [nuclear hormone receptor binding]
GO:0042593 [glucose homeostasis]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043565 [sequence-specific DNA binding]
GO:0043570 [maintenance of DNA repeat elements]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044334 [canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition]
GO:0045295 [gamma-catenin binding]
GO:0045444 [fat cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046827 [positive regulation of protein export from nucleus]
GO:0048625 [myoblast fate commitment]
GO:0048660 [regulation of smooth muscle cell proliferation]
GO:0048699 [generation of neurons]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060070 [canonical Wnt signaling pathway]
GO:0070016 [armadillo repeat domain binding]
GO:0070369 [beta-catenin-TCF7L2 complex]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:2000675 [negative regulation of type B pancreatic cell apoptotic process]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
 459 aa
51.2 kDa 		No 0
TCF7L2-202
ENSP00000347949
ENST00000355717
Q9NQB0 [Direct mapping]
Transcription factor 7-like 2
Show all
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001103 [RNA polymerase II repressing transcription factor binding]
GO:0001568 [blood vessel development]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007050 [cell cycle arrest]
GO:0008013 [beta-catenin binding]
GO:0008134 [transcription factor binding]
GO:0008283 [cell proliferation]
GO:0009749 [response to glucose]
GO:0010909 [positive regulation of heparan sulfate proteoglycan biosynthetic process]
GO:0016605 [PML body]
GO:0019901 [protein kinase binding]
GO:0031016 [pancreas development]
GO:0032024 [positive regulation of insulin secretion]
GO:0032092 [positive regulation of protein binding]
GO:0032350 [regulation of hormone metabolic process]
GO:0032993 [protein-DNA complex]
GO:0035257 [nuclear hormone receptor binding]
GO:0042593 [glucose homeostasis]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043565 [sequence-specific DNA binding]
GO:0043570 [maintenance of DNA repeat elements]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044334 [canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition]
GO:0045295 [gamma-catenin binding]
GO:0045444 [fat cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046827 [positive regulation of protein export from nucleus]
GO:0048625 [myoblast fate commitment]
GO:0048660 [regulation of smooth muscle cell proliferation]
GO:0048699 [generation of neurons]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060070 [canonical Wnt signaling pathway]
GO:0070016 [armadillo repeat domain binding]
GO:0070369 [beta-catenin-TCF7L2 complex]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:2000675 [negative regulation of type B pancreatic cell apoptotic process]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
 489 aa
54.6 kDa 		No 0
TCF7L2-203
ENSP00000348274
ENST00000355995
Q9NQB0 [Direct mapping]
Transcription factor 7-like 2
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001103 [RNA polymerase II repressing transcription factor binding]
GO:0001568 [blood vessel development]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007050 [cell cycle arrest]
GO:0008013 [beta-catenin binding]
GO:0008134 [transcription factor binding]
GO:0008283 [cell proliferation]
GO:0009749 [response to glucose]
GO:0010909 [positive regulation of heparan sulfate proteoglycan biosynthetic process]
GO:0016605 [PML body]
GO:0019901 [protein kinase binding]
GO:0031016 [pancreas development]
GO:0032024 [positive regulation of insulin secretion]
GO:0032092 [positive regulation of protein binding]
GO:0032350 [regulation of hormone metabolic process]
GO:0032993 [protein-DNA complex]
GO:0035257 [nuclear hormone receptor binding]
GO:0042593 [glucose homeostasis]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043565 [sequence-specific DNA binding]
GO:0043570 [maintenance of DNA repeat elements]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044334 [canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition]
GO:0045295 [gamma-catenin binding]
GO:0045444 [fat cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046827 [positive regulation of protein export from nucleus]
GO:0048625 [myoblast fate commitment]
GO:0048660 [regulation of smooth muscle cell proliferation]
GO:0048699 [generation of neurons]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060070 [canonical Wnt signaling pathway]
GO:0070016 [armadillo repeat domain binding]
GO:0070369 [beta-catenin-TCF7L2 complex]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:2000675 [negative regulation of type B pancreatic cell apoptotic process]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
 619 aa
67.9 kDa 		No 0
TCF7L2-204
ENSP00000443626
ENST00000534894
A0A0A0MTL7 [Direct mapping]
Transcription factor 7-like 2
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008013 [beta-catenin binding]
GO:0048699 [generation of neurons]
GO:0060070 [canonical Wnt signaling pathway]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
 408 aa
45.4 kDa 		No 0
TCF7L2-205
ENSP00000446238
ENST00000536810
C6ZRK5 [Direct mapping]
TCF7L2 isoform pFC8A_TCF7L2_ex1-11-13-14; Transcription factor 7-like 2; Transcription factor 7-like 2 (T-cell specific, HMG-box), isoform CRA_i
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008013 [beta-catenin binding]
GO:0048699 [generation of neurons]
GO:0060070 [canonical Wnt signaling pathway]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
 579 aa
63.4 kDa 		No 0
TCF7L2-206
ENSP00000446172
ENST00000538897
Q9NQB0 [Direct mapping]
Transcription factor 7-like 2
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001103 [RNA polymerase II repressing transcription factor binding]
GO:0001568 [blood vessel development]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007050 [cell cycle arrest]
GO:0008013 [beta-catenin binding]
GO:0008134 [transcription factor binding]
GO:0008283 [cell proliferation]
GO:0009749 [response to glucose]
GO:0010909 [positive regulation of heparan sulfate proteoglycan biosynthetic process]
GO:0016605 [PML body]
GO:0019901 [protein kinase binding]
GO:0031016 [pancreas development]
GO:0032024 [positive regulation of insulin secretion]
GO:0032092 [positive regulation of protein binding]
GO:0032350 [regulation of hormone metabolic process]
GO:0032993 [protein-DNA complex]
GO:0035257 [nuclear hormone receptor binding]
GO:0042593 [glucose homeostasis]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043565 [sequence-specific DNA binding]
GO:0043570 [maintenance of DNA repeat elements]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044334 [canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition]
GO:0045295 [gamma-catenin binding]
GO:0045444 [fat cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046827 [positive regulation of protein export from nucleus]
GO:0048625 [myoblast fate commitment]
GO:0048660 [regulation of smooth muscle cell proliferation]
GO:0048699 [generation of neurons]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060070 [canonical Wnt signaling pathway]
GO:0070016 [armadillo repeat domain binding]
GO:0070369 [beta-catenin-TCF7L2 complex]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:2000675 [negative regulation of type B pancreatic cell apoptotic process]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
 482 aa
53.7 kDa 		No 0
TCF7L2-207
ENSP00000443883
ENST00000542695
C6ZRJ6 [Direct mapping]
TCF7L2 isoform pFC8A_TCF7L2_D5_ex3,4a-11,12,13a,14; Transcription factor 7-like 2
Show all
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008013 [beta-catenin binding]
GO:0048699 [generation of neurons]
GO:0060070 [canonical Wnt signaling pathway]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
 534 aa
58.9 kDa 		No 0
TCF7L2-208
ENSP00000444972
ENST00000543371
E2GH26 [Direct mapping]
T-cell factor-4 variant L; Transcription factor 7-like 2
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008013 [beta-catenin binding]
GO:0048699 [generation of neurons]
GO:0060070 [canonical Wnt signaling pathway]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
 607 aa
66.6 kDa 		No 0
TCF7L2-209
ENSP00000440547
ENST00000545257
C6ZRJ7 [Direct mapping]
TCF7L2 isoform pFC8A_TCF7L2_A3,ex1-12,13,13a; Transcription factor 7-like 2
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008013 [beta-catenin binding]
GO:0048699 [generation of neurons]
GO:0060070 [canonical Wnt signaling pathway]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
 476 aa
53 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.