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Hepatocellular carcinomas showed moderate to strong cytoplasmic immunoreactivity. Several lymphomas, breast, prostate, ovarian and endometrial cancers showed moderate staining. Most other cancers were weakly stained or negative.
A majority of cancers showed weak cytoplasmic positivity with additional nuclear immunoreactivity in several cases. Several lymphomas were strongly stained. Several cases of colorectal, prostate, ovarian, cervical and endometrial were moderately stained.
GENE INFORMATION
Gene name
RGS10
Synonyms
Description
Regulator of G-protein signaling 10 (HGNC Symbol)
Entrez gene summary
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
