Fields »
ABOUT
HELP
BLOG
ADM

GENERAL INFORMATION

Gene name

 ADM

Gene description

 Adrenomedullin

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression and extracellular positivity in several tissues, including placenta, appendix and esophagus.

DATA RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Approved based on 1 antibody.
CAB016075
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ADM (HGNC Symbol)

Synonyms

 AM

Description

 Adrenomedullin (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. [provided by RefSeq, Aug 2014]

Chromosome

 11

Cytoband

 p15.4

Chromosome location (bp)

 10304680 - 10307397

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000148926 (version 83.38)

Entrez gene

 133

UniProt

 P35318 (UniProt - Evidence at protein level)

neXtProt

 NX_P35318

Antibodypedia

 ADM antibodies

PROTEIN BROWSER
ADM-001
ADM-002
ADM-003
ADM-004
ADM-005
ADM-006
ADM-007
ADM-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADM-001
ENSP00000278175
ENST00000278175
P35318 [Direct mapping]
ADM Adrenomedullin Proadrenomedullin N-20 terminal peptide
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001570 [vasculogenesis]
GO:0002031 [G-protein coupled receptor internalization]
GO:0005102 [receptor binding]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0006171 [cAMP biosynthetic process]
GO:0006701 [progesterone biosynthetic process]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0008015 [blood circulation]
GO:0019731 [antibacterial humoral response]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0031623 [receptor internalization]
GO:0045906 [negative regulation of vasoconstriction]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0050830 [defense response to Gram-positive bacterium]
Show all
 185 aa
20.4 kDa 		Yes 0
ADM-002
ENSP00000436607
ENST00000528655
P35318 [Direct mapping]
ADM Adrenomedullin Proadrenomedullin N-20 terminal peptide
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001570 [vasculogenesis]
GO:0001666 [response to hypoxia]
GO:0001843 [neural tube closure]
GO:0002026 [regulation of the force of heart contraction]
GO:0002031 [G-protein coupled receptor internalization]
GO:0005102 [receptor binding]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006171 [cAMP biosynthetic process]
GO:0006701 [progesterone biosynthetic process]
GO:0007165 [signal transduction]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007267 [cell-cell signaling]
GO:0007507 [heart development]
GO:0007565 [female pregnancy]
GO:0007568 [aging]
GO:0008015 [blood circulation]
GO:0008209 [androgen metabolic process]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0009409 [response to cold]
GO:0009611 [response to wounding]
GO:0010033 [response to organic substance]
GO:0010460 [positive regulation of heart rate]
GO:0019731 [antibacterial humoral response]
GO:0019933 [cAMP-mediated signaling]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0031100 [organ regeneration]
GO:0031102 [neuron projection regeneration]
GO:0031623 [receptor internalization]
GO:0031700 [adrenomedullin receptor binding]
GO:0032496 [response to lipopolysaccharide]
GO:0032868 [response to insulin]
GO:0042475 [odontogenesis of dentin-containing tooth]
GO:0042594 [response to starvation]
GO:0043065 [positive regulation of apoptotic process]
GO:0043116 [negative regulation of vascular permeability]
GO:0045766 [positive regulation of angiogenesis]
GO:0045906 [negative regulation of vasoconstriction]
GO:0045909 [positive regulation of vasodilation]
GO:0046879 [hormone secretion]
GO:0048589 [developmental growth]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0051384 [response to glucocorticoid]
GO:0055074 [calcium ion homeostasis]
GO:0060670 [branching involved in labyrinthine layer morphogenesis]
GO:0060712 [spongiotrophoblast layer development]
GO:0097084 [vascular smooth muscle cell development]
GO:2001214 [positive regulation of vasculogenesis]
Show all
 185 aa
20.4 kDa 		Yes 0
ADM-003
ENSP00000431438
ENST00000534464
E9PL83 [Direct mapping]
ADM
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
Show all
 138 aa
15.1 kDa 		No 0
ADM-004
ENSP00000436837
ENST00000530439
E9PQE6 [Direct mapping]
ADM
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
Show all
 117 aa
12.9 kDa 		No 0
ADM-005
ENSP00000433062
ENST00000524948
E9PML4 [Direct mapping]
ADM
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
Show all
 83 aa
9.2 kDa 		Yes 0
ADM-006
ENSP00000434354
ENST00000526492
E9PQT2 [Direct mapping]
ADM
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
Show all
 139 aa
15.2 kDa 		Yes 0
ADM-007
ENSP00000435124
ENST00000525063
P35318 [Direct mapping]
ADM Adrenomedullin Proadrenomedullin N-20 terminal peptide
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001570 [vasculogenesis]
GO:0002031 [G-protein coupled receptor internalization]
GO:0005102 [receptor binding]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0006171 [cAMP biosynthetic process]
GO:0006701 [progesterone biosynthetic process]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0008015 [blood circulation]
GO:0019731 [antibacterial humoral response]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0031623 [receptor internalization]
GO:0045906 [negative regulation of vasoconstriction]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0050830 [defense response to Gram-positive bacterium]
Show all
 185 aa
20.4 kDa 		Yes 0
ADM-008
ENSP00000434749
ENST00000528544
E9PML4 [Direct mapping]
ADM
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
Show all
 83 aa
9.2 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.