Expression of SLC5A12 in cancer - Summary

CANCER ATLAS

Gene description

Solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12

Protein class

Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Renal cancer

STAINING SUMMARY

HPA060904

GENE INFORMATION
Gene name	SLC5A12 (HGNC Symbol)
Synonyms	MGC52019, SMCT2
Description	Solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12 (HGNC Symbol)
Entrez gene summary	Normal blood lactate is maintained at about 1.5 mM, and little filtered lactate is excreted in urine. Reabsorption of lactate is mediated by the low-affinity Na(+)-coupled lactate transporter SLC5A12 in the initial part of the proximal tubule and by the high-affinity Na(+)-coupled lactate transporter SLC5A8 (MIM 608044) in the distal proximal tubule (Gopal et al., 2007 [PubMed 17692818]).[supplied by OMIM, Dec 2008]
Chromosome	11
Cytoband	p14.2
Chromosome location (bp)	26667019 - 26723427
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000148942 (version 83.38)
Entrez gene	159963
UniProt	Q1EHB4 (UniProt - Evidence at transcript level)
neXtProt	NX_Q1EHB4
Antibodypedia	SLC5A12 antibodies

PROTEIN BROWSER

SLC5A12-001	SLC5A12-002	SLC5A12-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC5A12-001 ENSP00000379326 ENST00000396005	Q1EHB4 [Direct mapping] Sodium-coupled monocarboxylate transporter 2 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0006810 [transport] GO:0006814 [sodium ion transport] GO:0015129 [lactate transmembrane transporter activity] GO:0015293 [symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0035873 [lactate transmembrane transport] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] Show all	618 aa 67.6 kDa	No	>9
SLC5A12-002 ENSP00000280467 ENST00000280467	Q1EHB4 [Direct mapping] Sodium-coupled monocarboxylate transporter 2 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0006810 [transport] GO:0006814 [sodium ion transport] GO:0015293 [symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] Show all	396 aa 44.1 kDa	No	9
SLC5A12-004 ENSP00000435053 ENST00000533617	E9PLZ7 [Direct mapping] Sodium-coupled monocarboxylate transporter 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0006810 [transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	151 aa 16.9 kDa	Yes	2