Expression of PGAP2 in cancer - Summary

CANCER ATLAS

Gene description

Post-GPI attachment to proteins 2

Protein class

Disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA063099

GENE INFORMATION
Gene name	PGAP2 (HGNC Symbol)
Synonyms	CWH43-N, FRAG1, MRT21
Description	Post-GPI attachment to proteins 2 (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	p15.4
Chromosome location (bp)	3797724 - 3826371
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000148985 (version 83.38)
Entrez gene	27315
UniProt	Q9UHJ9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UHJ9
Antibodypedia	PGAP2 antibodies

PROTEIN BROWSER

PGAP2-001	PGAP2-002	PGAP2-003	PGAP2-007	PGAP2-008	PGAP2-009	PGAP2-010	PGAP2-011	PGAP2-015	PGAP2-017	PGAP2-019	PGAP2-023	PGAP2-024	PGAP2-029	PGAP2-039	PGAP2-041	PGAP2-049	PGAP2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PGAP2-001 ENSP00000278243 ENST00000278243	Q9UHJ9 [Direct mapping] Post-GPI attachment to proteins factor 2 A0A024RCC6 [Target identity:100%; Query identity:100%] FGF receptor activating protein 1, isoform CRA_d Show all	Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005789 [endoplasmic reticulum membrane] GO:0006506 [GPI anchor biosynthetic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0008565 [protein transporter activity] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0015031 [protein transport] GO:0016021 [integral component of membrane] GO:0042770 [signal transduction in response to DNA damage] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:1902230 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage] Show all	315 aa 36.4 kDa	No	6
PGAP2-002 ENSP00000380183 ENST00000396986	A8MYS5 [Direct mapping] Post-GPI attachment to proteins factor 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	311 aa 35.5 kDa	No	6
PGAP2-003 ENSP00000300730 ENST00000300730	Q9UHJ9 [Direct mapping] Post-GPI attachment to proteins factor 2 Show all	Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006506 [GPI anchor biosynthetic process] GO:0008565 [protein transporter activity] GO:0015031 [protein transport] GO:0016021 [integral component of membrane] Show all	307 aa 35.1 kDa	No	6
PGAP2-007 ENSP00000433377 ENST00000532523	H0YDC6 [Direct mapping] Post-GPI attachment to proteins factor 2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all		182 aa 20 kDa	No	0
PGAP2-008 ENSP00000433748 ENST00000459679	H0YDJ5 [Direct mapping] Post-GPI attachment to proteins factor 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	208 aa 23.3 kDa	No	3
PGAP2-009 ENSP00000434772 ENST00000464229	E9PKT0 [Direct mapping] Post-GPI attachment to proteins factor 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	94 aa 11.4 kDa	No	2
PGAP2-010 ENSP00000434088 ENST00000464261	H0YDQ4 [Direct mapping] FGF receptor activating protein 1, isoform CRA_c; Post-GPI attachment to proteins factor 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	234 aa 26 kDa	No	4
PGAP2-011 ENSP00000435703 ENST00000490830	H0YEE9 [Direct mapping] Post-GPI attachment to proteins factor 2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all		78 aa 8.4 kDa	No	0
PGAP2-015 ENSP00000431851 ENST00000493547	Q9UHJ9 [Direct mapping] Post-GPI attachment to proteins factor 2 Show all	Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006506 [GPI anchor biosynthetic process] GO:0008565 [protein transporter activity] GO:0015031 [protein transport] GO:0016021 [integral component of membrane] Show all	232 aa 25.8 kDa	No	4
PGAP2-017 ENSP00000435799 ENST00000464441	A8MZF5 [Direct mapping] Post-GPI attachment to proteins factor 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	98 aa 11.8 kDa	No	2
PGAP2-019 ENSP00000432721 ENST00000496834	E9PPF7 [Direct mapping] Post-GPI attachment to proteins factor 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all		98 aa 11.8 kDa	No	2
PGAP2-023 ENSP00000435338 ENST00000479072	E9PKT0 [Direct mapping] Post-GPI attachment to proteins factor 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	94 aa 11.4 kDa	No	2
PGAP2-024 ENSP00000434507 ENST00000469307	E9PQ19 [Direct mapping] Post-GPI attachment to proteins factor 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	245 aa 28.3 kDa	No	5
PGAP2-029 ENSP00000380190 ENST00000396993	A8MZF5 [Direct mapping] Post-GPI attachment to proteins factor 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	98 aa 11.8 kDa	No	2
PGAP2-039 ENSP00000434631 ENST00000464906	Q9UHJ9 [Direct mapping] Post-GPI attachment to proteins factor 2 A0A024RCC6 [Target identity:100%; Query identity:100%] FGF receptor activating protein 1, isoform CRA_d Show all	Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006506 [GPI anchor biosynthetic process] GO:0008565 [protein transporter activity] GO:0015031 [protein transport] GO:0016021 [integral component of membrane] Show all	315 aa 36.4 kDa	No	6
PGAP2-041 ENSP00000434401 ENST00000465307	B7Z2X5 [Direct mapping] Post-GPI attachment to proteins factor 2; cDNA FLJ54959 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all		211 aa 23.1 kDa	No	0
PGAP2-049 ENSP00000435223 ENST00000463452	Q9UHJ9 [Direct mapping] Post-GPI attachment to proteins factor 2 A0A024RCD5 [Target identity:100%; Query identity:100%] FGF receptor activating protein 1, isoform CRA_a Show all	Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006506 [GPI anchor biosynthetic process] GO:0008565 [protein transporter activity] GO:0015031 [protein transport] GO:0016021 [integral component of membrane] Show all	254 aa 29.4 kDa	No	5
PGAP2-201 ENSP00000380188 ENST00000396991	A0A0A0MS75 [Direct mapping] FGF receptor activating protein 1, isoform CRA_e; Post-GPI attachment to proteins factor 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	272 aa 30.9 kDa	No	5