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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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SCGB1A1
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  • CELL

  • CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

SCGB1A1

Gene description

Secretoglobin, family 1A, member 1 (uteroglobin)

Protein class

Cancer-related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (lung)
GTEx:Tissue enriched (lung)
FANTOM5:Tissue enriched (lung)

Protein evidence

Evidence at protein level

Protein expression

Selective cytoplasmic expression in a subset of respiratory epithelial cells in bronchus.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Protein expression in respiratory epithelia can be correlated with lung RNA-seq data.

Reliability score

Supported based on 2 antibodies.
HPA031828 , CAB025686
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Bronchus

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (lung)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (lung)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (lung)

GENE INFORMATION

Gene name

SCGB1A1 (HGNC Symbol)

Synonyms

CC10, CC16, CCSP, UGB

Description

Secretoglobin, family 1A, member 1 (uteroglobin) (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the secretoglobin family of small secreted proteins. The encoded protein has been implicated in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. Defects in this gene are associated with a susceptibility to asthma. [provided by RefSeq, May 2010]

Chromosome

11

Cytoband

q12.3

Chromosome location (bp)

62405103 - 62423195

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000149021 (version 83.38)

Entrez gene

7356

UniProt

P11684 (UniProt - Evidence at protein level)

neXtProt

NX_P11684

Antibodypedia

SCGB1A1 antibodies

PROTEIN BROWSER

SCGB1A1-001
SCGB1A1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SCGB1A1-001
ENSP00000278282
ENST00000278282
P11684 [Direct mapping]
Uteroglobin
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005791 [rough endoplasmic reticulum]
GO:0007165 [signal transduction]
GO:0007565 [female pregnancy]
GO:0007566 [embryo implantation]
GO:0009410 [response to xenobiotic stimulus]
GO:0010033 [response to organic substance]
GO:0010193 [response to ozone]
GO:0019834 [phospholipase A2 inhibitor activity]
GO:0030141 [secretory granule]
GO:0032496 [response to lipopolysaccharide]
GO:0032689 [negative regulation of interferon-gamma production]
GO:0032696 [negative regulation of interleukin-13 production]
GO:0032713 [negative regulation of interleukin-4 production]
GO:0032714 [negative regulation of interleukin-5 production]
GO:0034021 [response to silicon dioxide]
GO:0034097 [response to cytokine]
GO:0042130 [negative regulation of T cell proliferation]
GO:0042493 [response to drug]
GO:0043086 [negative regulation of catalytic activity]
GO:0043488 [regulation of mRNA stability]
GO:0050727 [regulation of inflammatory response]
GO:0051384 [response to glucocorticoid]
GO:0070062 [extracellular exosome]
GO:0071774 [response to fibroblast growth factor]
GO:0097160 [polychlorinated biphenyl binding]
Show all
91 aa
10 kDa
Yes 0
SCGB1A1-002
ENSP00000432866
ENST00000534397
E9PN95 [Direct mapping]
Uteroglobin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007165 [signal transduction]
Show all
56 aa
6.3 kDa
No 0

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