Cell atlas - APIP - The Human Protein Atlas

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APIP

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	APIP
Gene description	APAF1 interacting protein
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)
Additional location	In addition localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA021188
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

Nucleoplasm (approved)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA021188	PC-3	Nucleoplasm
	HPA021188	PC-3	Cytosol
	HPA021188	RH-30	Nucleoplasm
	HPA021188	RH-30	Cytosol
	HPA021188	U-2 OS	Nucleoplasm

GENE INFORMATION
Gene name	APIP (HGNC Symbol)
Synonyms	APIP2, CGI-29, Mmrp19
Description	APAF1 interacting protein (HGNC Symbol)
Entrez gene summary	APIP is an APAF1 (MIM 602233)-interacting protein that acts as a negative regulator of ischemic/hypoxic injury (Cho et al., 2004 [PubMed 15262985]).[supplied by OMIM, Dec 2008]
Chromosome	11
Cytoband	p13
Chromosome location (bp)	34853094 - 34916499
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000149089 (version 83.38)
Entrez gene	51074
UniProt	Q96GX9 (UniProt - Evidence at protein level)
neXtProt	NX_Q96GX9
Antibodypedia	APIP antibodies

PROTEIN BROWSER

APIP-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
APIP-001 ENSP00000379133 ENST00000395787	Q96GX9 [Direct mapping] Methylthioribulose-1-phosphate dehydratase Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000096 [sulfur amino acid metabolic process] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006595 [polyamine metabolic process] GO:0006915 [apoptotic process] GO:0008270 [zinc ion binding] GO:0019284 [L-methionine biosynthetic process from S-adenosylmethionine] GO:0019509 [L-methionine biosynthetic process from methylthioadenosine] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042802 [identical protein binding] GO:0043066 [negative regulation of apoptotic process] GO:0044281 [small molecule metabolic process] GO:0046570 [methylthioribulose 1-phosphate dehydratase activity] GO:0046872 [metal ion binding] GO:0070372 [regulation of ERK1 and ERK2 cascade] Show all	242 aa 27.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.