Cell atlas - SESN3 - The Human Protein Atlas

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SESN3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	SESN3
Gene description	Sestrin 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the cytosol.
RNA cell category	Cell line enhanced (ASC TERT1, AF22)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)
Additional location	In addition localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA037935
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (ASC TERT1, AF22) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

Nucleoplasm (approved)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA037935	HeLa	Nucleoplasm
	HPA037935	HeLa	Cytosol
	HPA037935	RT4	Nucleoplasm
	HPA037935	RT4	Cytosol
	HPA037935	U-2 OS	Nucleoplasm
	HPA037935	U-2 OS	Cytosol

GENE INFORMATION
Gene name	SESN3 (HGNC Symbol)
Synonyms	MGC29667, SEST3
Description	Sestrin 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
Chromosome	11
Cytoband	q21
Chromosome location (bp)	95165513 - 95232541
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000149212 (version 83.38)
Entrez gene	143686
UniProt	P58005 (UniProt - Evidence at transcript level)
neXtProt	NX_P58005
Antibodypedia	SESN3 antibodies

PROTEIN BROWSER

SESN3-001	SESN3-002	SESN3-003	SESN3-004	SESN3-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SESN3-001 ENSP00000441927 ENST00000536441	P58005 [Direct mapping] Sestrin-3 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0032868 [response to insulin] GO:0042593 [glucose homeostasis] GO:0051896 [regulation of protein kinase B signaling] GO:1901031 [regulation of response to reactive oxygen species] Show all	492 aa 57.3 kDa	No	0
SESN3-002 ENSP00000407008 ENST00000416495	P58005 [Direct mapping] Sestrin-3 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:1901031 [regulation of response to reactive oxygen species] Show all	321 aa 36.6 kDa	No	0
SESN3-003 ENSP00000278499 ENST00000278499	P58005 [Direct mapping] Sestrin-3 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:1901031 [regulation of response to reactive oxygen species] Show all	353 aa 41.5 kDa	No	0
SESN3-004 ENSP00000439580 ENST00000542176	F5H1K7 [Direct mapping] Sestrin-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:1901031 [regulation of response to reactive oxygen species] Show all	70 aa 8.1 kDa	No	0
SESN3-006 ENSP00000489281 ENST00000634898		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:1901031 [regulation of response to reactive oxygen species] Show all	84 aa 9.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.