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TKFC

CANCER ATLAS

Gene description

 Triokinase/FMN cyclase

Protein class

 Enzymes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA039486
HPA048186

GENE INFORMATION

Gene name

 TKFC (HGNC Symbol)

Synonyms

 DAK, DKFZP586B1621, NET45

Description

 Triokinase/FMN cyclase (HGNC Symbol)

Entrez gene summary

 This gene is a member of the family of dihydroxyacetone kinases, which have a protein structure distinct from other kinases. The product of this gene phosphorylates dihydroxyacetone, and also catalyzes the formation of riboflavin 4',5'-phosphate (aka cyclin FMN) from FAD. Several alternatively spliced transcript variants have been identified, but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q12.2

Chromosome location (bp)

 61333210 - 61353295

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000149476 (version 83.38)

Entrez gene

 26007

UniProt

 Q3LXA3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q3LXA3

Antibodypedia

 TKFC antibodies

PROTEIN BROWSER
TKFC-001
TKFC-004
TKFC-005
TKFC-016
TKFC-023
TKFC-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TKFC-001
ENSP00000378360
ENST00000394900
Q3LXA3 [Direct mapping]
Triokinase/FMN cyclase ATP-dependent dihydroxyacetone kinase FAD-AMP lyase (cyclizing)
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Enzymes
   ENZYME proteins
   Transferases
   Lyases
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004371 [glycerone kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006000 [fructose metabolic process]
GO:0006071 [glycerol metabolic process]
GO:0034012 [FAD-AMP lyase (cyclizing) activity]
GO:0039534 [negative regulation of MDA-5 signaling pathway]
GO:0044262 [cellular carbohydrate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0045088 [regulation of innate immune response]
GO:0046835 [carbohydrate phosphorylation]
GO:0046872 [metal ion binding]
GO:0050354 [triokinase activity]
GO:0061624 [fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate]
GO:0070062 [extracellular exosome]
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 575 aa
58.9 kDa 		No 0
TKFC-004
ENSP00000432539
ENST00000529479
H0YCY6 [Direct mapping]
Protein TKFC
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004371 [glycerone kinase activity]
GO:0005524 [ATP binding]
GO:0006071 [glycerol metabolic process]
GO:0016310 [phosphorylation]
Show all
 533 aa
54.7 kDa 		No 0
TKFC-005
ENSP00000431844
ENST00000532173
E9PJG8 [Direct mapping]
Protein TKFC
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004371 [glycerone kinase activity]
GO:0006071 [glycerol metabolic process]
GO:0016310 [phosphorylation]
Show all
 162 aa
16.5 kDa 		No 0
TKFC-016
ENSP00000434405
ENST00000524968
E9PQR1 [Direct mapping]
Protein TKFC
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004371 [glycerone kinase activity]
GO:0006071 [glycerol metabolic process]
GO:0016310 [phosphorylation]
Show all
 57 aa
5.8 kDa 		No 0
TKFC-023
ENSP00000459382
ENST00000534084
I3L252 [Direct mapping]
Protein TKFC
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004371 [glycerone kinase activity]
GO:0006071 [glycerol metabolic process]
GO:0016310 [phosphorylation]
Show all
 219 aa
23 kDa 		No 0
TKFC-201
ENSP00000478735
ENST00000617083
A0A087WUL0 [Direct mapping]
Protein TKFC
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004371 [glycerone kinase activity]
GO:0005524 [ATP binding]
GO:0006071 [glycerol metabolic process]
GO:0016310 [phosphorylation]
Show all
 576 aa
59.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.