Expression of TMEM138 in cancer - Summary

CANCER ATLAS

Gene description

Transmembrane protein 138

Protein class

Disease related genes, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Skin cancer

STAINING SUMMARY

HPA042373

GENE INFORMATION
Gene name	TMEM138 (HGNC Symbol)
Synonyms	HSPC196, JBTS16
Description	Transmembrane protein 138 (HGNC Symbol)
Entrez gene summary	This gene encodes a multi-pass transmembrane protein. Reduced expression of this gene in mouse fibroblasts causes short cilia and failure of ciliogenesis. Expression of this gene is tightly coordinated with expression of the neighboring gene TMEM216. Mutations in this gene are associated with the autosomal recessive neurodevelopmental disorder Joubert Syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
Chromosome	11
Cytoband	q12.2
Chromosome location (bp)	61362001 - 61369509
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000149483 (version 83.38)
Entrez gene	51524
UniProt	Q9NPI0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NPI0
Antibodypedia	TMEM138 antibodies

PROTEIN BROWSER

TMEM138-001	TMEM138-009	TMEM138-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMEM138-001 ENSP00000278826 ENST00000278826	Q9NPI0 [Direct mapping] Transmembrane protein 138 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005774 [vacuolar membrane] GO:0005929 [cilium] GO:0016021 [integral component of membrane] GO:0042384 [cilium assembly] Show all	162 aa 19.3 kDa	No	4
TMEM138-009 ENSP00000445792 ENST00000542946	Q9NPI0 [Direct mapping] Transmembrane protein 138 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005774 [vacuolar membrane] GO:0005929 [cilium] GO:0016021 [integral component of membrane] GO:0042384 [cilium assembly] Show all	105 aa 12.1 kDa	No	3
TMEM138-011 ENSP00000371206 ENST00000381787	J3QSZ6 [Direct mapping] Transmembrane protein 138 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	104 aa 12.6 kDa	No	2