Tissue expression of FADS1 - Summary - The Human Protein Atlas

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FADS1

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	FADS1
Gene description	Fatty acid desaturase 1
Protein class	FDA approved drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	17
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

General cytoplasmic expression.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA042705
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	FADS1 (HGNC Symbol)
Synonyms	D5D, FADS6, FADSD5, LLCDL1, TU12
Description	Fatty acid desaturase 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q12.2
Chromosome location (bp)	61799625 - 61829318
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000149485 (version 83.38)
Entrez gene	3992
UniProt	O60427 (UniProt - Evidence at protein level)
neXtProt	NX_O60427
Antibodypedia	FADS1 antibodies

PROTEIN BROWSER

FADS1-001	FADS1-002	FADS1-004	FADS1-005	FADS1-006	FADS1-007	FADS1-009	FADS1-010	FADS1-012	FADS1-013	FADS1-014	FADS1-016	FADS1-017	FADS1-018	FADS1-019	FADS1-020	FADS1-022

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FADS1-001 ENSP00000322229 ENST00000350997	A0A0A0MR51 [Direct mapping] Fatty acid desaturase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0006629 [lipid metabolic process] GO:0007568 [aging] GO:0007584 [response to nutrient] GO:0009744 [response to sucrose] GO:0010033 [response to organic substance] GO:0014070 [response to organic cyclic compound] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0016717 [oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water] GO:0019369 [arachidonic acid metabolic process] GO:0032868 [response to insulin] GO:0033189 [response to vitamin A] GO:0035900 [response to isolation stress] GO:0043231 [intracellular membrane-bounded organelle] GO:0055114 [oxidation-reduction process] Show all	501 aa 57.9 kDa	No	5
FADS1-002 ENSP00000405087 ENST00000433932	O60427 [Direct mapping] Fatty acid desaturase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0000248 [C-5 sterol desaturase activity] GO:0005739 [mitochondrion] GO:0005789 [endoplasmic reticulum membrane] GO:0006355 [regulation of transcription, DNA-templated] GO:0006629 [lipid metabolic process] GO:0006636 [unsaturated fatty acid biosynthetic process] GO:0007267 [cell-cell signaling] GO:0008654 [phospholipid biosynthetic process] GO:0009267 [cellular response to starvation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0033559 [unsaturated fatty acid metabolic process] GO:0036109 [alpha-linolenic acid metabolic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0043651 [linoleic acid metabolic process] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045595 [regulation of cell differentiation] GO:0046456 [icosanoid biosynthetic process] GO:0055114 [oxidation-reduction process] Show all	360 aa 42.5 kDa	No	4
FADS1-004 ENSP00000445253 ENST00000460649	F5H3P6 [Direct mapping] Fatty acid desaturase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006629 [lipid metabolic process] GO:0016021 [integral component of membrane] Show all	146 aa 17.3 kDa	No	1
FADS1-005 ENSP00000416043 ENST00000421879	C9JJB3 [Direct mapping] Fatty acid desaturase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006629 [lipid metabolic process] GO:0016021 [integral component of membrane] Show all	139 aa 16 kDa	No	2
FADS1-006 ENSP00000391229 ENST00000448607	C9J425 [Direct mapping] Fatty acid desaturase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		47 aa 5.4 kDa	No	0
FADS1-007 ENSP00000429016 ENST00000491310	H0YB97 [Direct mapping] Fatty acid desaturase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	175 aa 19.7 kDa	No	2
FADS1-009 ENSP00000446270 ENST00000466716	F5H2H3 [Direct mapping] Fatty acid desaturase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	111 aa 12.7 kDa	No	2
FADS1-010 ENSP00000445442 ENST00000473263	F5H2R9 [Direct mapping] Fatty acid desaturase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		16 aa 1.8 kDa	No	0
FADS1-012 ENSP00000441403 ENST00000542506	O60427 [Direct mapping] Fatty acid desaturase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0000248 [C-5 sterol desaturase activity] GO:0005739 [mitochondrion] GO:0005789 [endoplasmic reticulum membrane] GO:0006355 [regulation of transcription, DNA-templated] GO:0006629 [lipid metabolic process] GO:0006636 [unsaturated fatty acid biosynthetic process] GO:0007267 [cell-cell signaling] GO:0008654 [phospholipid biosynthetic process] GO:0009267 [cellular response to starvation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0033559 [unsaturated fatty acid metabolic process] GO:0036109 [alpha-linolenic acid metabolic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0043651 [linoleic acid metabolic process] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045595 [regulation of cell differentiation] GO:0046456 [icosanoid biosynthetic process] GO:0055114 [oxidation-reduction process] Show all	360 aa 42.5 kDa	No	4
FADS1-013 ENSP00000443587 ENST00000539999	F5H8G5 [Direct mapping] Fatty acid desaturase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	124 aa 15.3 kDa	No	2
FADS1-014 ENSP00000439790 ENST00000544309	F5H0Y2 [Direct mapping] Fatty acid desaturase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	109 aa 12.4 kDa	No	2
FADS1-016 ENSP00000441871 ENST00000540767	F5GWE3 [Direct mapping] Fatty acid desaturase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006629 [lipid metabolic process] GO:0016021 [integral component of membrane] Show all	165 aa 19 kDa	No	2
FADS1-017 ENSP00000443037 ENST00000544696	F5H5X5 [Direct mapping] Fatty acid desaturase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	112 aa 12.8 kDa	No	2
FADS1-018 ENSP00000440652 ENST00000545405	F5GYH4 [Direct mapping] Fatty acid desaturase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006629 [lipid metabolic process] GO:0016021 [integral component of membrane] Show all	153 aa 17.7 kDa	No	2
FADS1-019 ENSP00000442170 ENST00000545245	F5H852 [Direct mapping] Fatty acid desaturase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006629 [lipid metabolic process] GO:0016021 [integral component of membrane] Show all	164 aa 18.9 kDa	No	2
FADS1-020 ENSP00000438997 ENST00000539419	F5H1Q7 [Direct mapping] Fatty acid desaturase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	86 aa 9.8 kDa	No	1
FADS1-022 ENSP00000439097 ENST00000536991	F5H3U5 [Direct mapping] Fatty acid desaturase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006629 [lipid metabolic process] GO:0016021 [integral component of membrane] Show all	192 aa 22.7 kDa	Yes	3

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