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Gene name

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Subclass

Chromosome

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In atlas

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Reliability

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Method

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Method

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Expression

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Specificity

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Detectable

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MS4A3
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

MS4A3

Gene description

Membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)

Protein class

Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Membrane,Secreted

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (bone marrow)
GTEx:Group enriched (spleen, lung, testis)
FANTOM5:Tissue enhanced (heart muscle, lung, spleen)

Protein evidence

Evidence at protein level

Protein expression

Distinct cytoplasmic expression in hematopoietic cells.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

Supported based on 1 antibody.
HPA019210
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (bone marrow)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (spleen, lung, testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (heart muscle, lung, spleen)

GENE INFORMATION

Gene name

MS4A3 (HGNC Symbol)

Synonyms

CD20L, HTM4

Description

Membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the membrane-spanning 4A gene family. Members of this protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member likely plays a role in signal transduction and may function as a subunit associated with receptor complexes. The gene encoding this protein is localized to 11q12, among a cluster of related family members. Alternative splicing may result in multiple transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

q12.1

Chromosome location (bp)

60056587 - 60071128

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000149516 (version 83.38)

Entrez gene

932

UniProt

Q96HJ5 (UniProt - Evidence at protein level)

neXtProt

NX_Q96HJ5

Antibodypedia

MS4A3 antibodies

PROTEIN BROWSER

MS4A3-001
MS4A3-002
MS4A3-003
MS4A3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MS4A3-001
ENSP00000278865
ENST00000278865
Q96HJ5 [Direct mapping]
Membrane-spanning 4-domains subfamily A member 3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0012505 [endomembrane system]
GO:0016021 [integral component of membrane]
GO:0048471 [perinuclear region of cytoplasm]
Show all
214 aa
22.9 kDa
No 4
MS4A3-002
ENSP00000434117
ENST00000534744
Q96HJ5 [Direct mapping]
Membrane-spanning 4-domains subfamily A member 3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0005515 [protein binding]
GO:0012505 [endomembrane system]
GO:0016021 [integral component of membrane]
GO:0048471 [perinuclear region of cytoplasm]
Show all
168 aa
17.6 kDa
No 2
MS4A3-003
ENSP00000378473
ENST00000395032
Q96HJ5 [Direct mapping]
Membrane-spanning 4-domains subfamily A member 3
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0005515 [protein binding]
GO:0012505 [endomembrane system]
GO:0016021 [integral component of membrane]
GO:0048471 [perinuclear region of cytoplasm]
Show all
91 aa
9.6 kDa
Yes 0
MS4A3-201
ENSP00000350872
ENST00000358152
Q96HJ5 [Direct mapping]
Membrane-spanning 4-domains subfamily A member 3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0005515 [protein binding]
GO:0012505 [endomembrane system]
GO:0016021 [integral component of membrane]
GO:0048471 [perinuclear region of cytoplasm]
Show all
168 aa
17.6 kDa
No 2

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