Expression of B3GAT3 in cancer - Summary

CANCER ATLAS

Gene description

Beta-1,3-glucuronyltransferase 3

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA051328

GENE INFORMATION
Gene name	B3GAT3 (HGNC Symbol)
Synonyms	GlcAT-I
Description	Beta-1,3-glucuronyltransferase 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the glucuronyltransferase gene family, enzymes that exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product catalyzes the formation of the glycosaminoglycan-protein linkage by way of a glucuronyl transfer reaction in the final step of the biosynthesis of the linkage region of proteoglycans. A pseudogene of this gene has been identified on chromosome 3. [provided by RefSeq, Dec 2013]
Chromosome	11
Cytoband	q12.3
Chromosome location (bp)	62615296 - 62622175
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000149541 (version 83.38)
Entrez gene	26229
UniProt	O94766 (UniProt - Evidence at protein level)
neXtProt	NX_O94766
Antibodypedia	B3GAT3 antibodies

PROTEIN BROWSER

B3GAT3-001	B3GAT3-002	B3GAT3-004	B3GAT3-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
B3GAT3-001 ENSP00000265471 ENST00000265471	O94766 [Direct mapping] Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] GO:0005801 [cis-Golgi network] GO:0005975 [carbohydrate metabolic process] GO:0006024 [glycosaminoglycan biosynthetic process] GO:0006486 [protein glycosylation] GO:0015012 [heparan sulfate proteoglycan biosynthetic process] GO:0015018 [galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity] GO:0015020 [glucuronosyltransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030203 [glycosaminoglycan metabolic process] GO:0030204 [chondroitin sulfate metabolic process] GO:0043085 [positive regulation of catalytic activity] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0050650 [chondroitin sulfate proteoglycan biosynthetic process] GO:0050651 [dermatan sulfate proteoglycan biosynthetic process] GO:0070062 [extracellular exosome] GO:0072542 [protein phosphatase activator activity] GO:0090316 [positive regulation of intracellular protein transport] Show all	335 aa 37.1 kDa	Yes	0
B3GAT3-002 ENSP00000431359 ENST00000531383	G3V150 [Direct mapping] Beta-1,3-glucuronyltransferase 3 (Glucuronosyltransferase I), isoform CRA_a; Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0015018 [galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity] GO:0016020 [membrane] Show all	319 aa 35 kDa	Yes	0
B3GAT3-004 ENSP00000432474 ENST00000534026	O94766 [Direct mapping] Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] GO:0005801 [cis-Golgi network] GO:0005975 [carbohydrate metabolic process] GO:0006024 [glycosaminoglycan biosynthetic process] GO:0006486 [protein glycosylation] GO:0015012 [heparan sulfate proteoglycan biosynthetic process] GO:0015018 [galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity] GO:0015020 [glucuronosyltransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030203 [glycosaminoglycan metabolic process] GO:0030204 [chondroitin sulfate metabolic process] GO:0043085 [positive regulation of catalytic activity] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0050650 [chondroitin sulfate proteoglycan biosynthetic process] GO:0050651 [dermatan sulfate proteoglycan biosynthetic process] GO:0070062 [extracellular exosome] GO:0072542 [protein phosphatase activator activity] GO:0090316 [positive regulation of intracellular protein transport] Show all	315 aa 34.6 kDa	Yes	0
B3GAT3-005 ENSP00000432854 ENST00000534715	E9PNA1 [Direct mapping] Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0015018 [galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	223 aa 24.5 kDa	No	0