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FEZ1

GENERAL INFORMATION

Gene name

 FEZ1

Gene description

 Fasciculation and elongation protein zeta 1 (zygin I)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Group enriched (hippocampus, hypothalamus, caudate, cerebral cortex, cerebellum)
FANTOM5:Group enriched (brain, cerebellum, hippocampus, caudate)

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (hippocampus, hypothalamus, caudate, cerebral cortex, cerebellum)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (brain, cerebellum, hippocampus, caudate)

GENE INFORMATION

Gene name

 FEZ1

Synonyms

Description

 Fasciculation and elongation protein zeta 1 (zygin I) (HGNC Symbol)

Entrez gene summary

 This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q24.2

Chromosome location (bp)

 125445745 - 125496317

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000149557 (version 83.38)

Entrez gene

 9638

UniProt

 Q99689 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99689

Antibodypedia

 FEZ1 antibodies

PROTEIN BROWSER
FEZ1-001
FEZ1-004
FEZ1-005
FEZ1-006
FEZ1-017

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FEZ1-001
ENSP00000278919
ENST00000278919
Q99689 [Direct mapping]
Fasciculation and elongation protein zeta-1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005794 [Golgi apparatus]
GO:0005813 [centrosome]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0007155 [cell adhesion]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0010976 [positive regulation of neuron projection development]
GO:0015630 [microtubule cytoskeleton]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0042995 [cell projection]
GO:0043015 [gamma-tubulin binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0047485 [protein N-terminus binding]
GO:0051654 [establishment of mitochondrion localization]
GO:0071363 [cellular response to growth factor stimulus]
GO:1902902 [negative regulation of autophagosome assembly]
Show all
 392 aa
45.1 kDa 		No 0
FEZ1-004
ENSP00000434803
ENST00000527534
E9PNH2 [Direct mapping]
Fasciculation and elongation protein zeta-1
Show all
Predicted intracellular proteins
Show all
GO:0005737 [cytoplasm]
GO:0015630 [microtubule cytoskeleton]
Show all
 79 aa
9.1 kDa 		No 0
FEZ1-005
ENSP00000431521
ENST00000524435
Q99689 [Direct mapping]
Fasciculation and elongation protein zeta-1
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0007155 [cell adhesion]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0015630 [microtubule cytoskeleton]
GO:1902902 [negative regulation of autophagosome assembly]
Show all
 104 aa
12.1 kDa 		No 0
FEZ1-006
ENSP00000393425
ENST00000366139
Q99689 [Direct mapping]
Fasciculation and elongation protein zeta-1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0007155 [cell adhesion]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0015630 [microtubule cytoskeleton]
GO:1902902 [negative regulation of autophagosome assembly]
Show all
 104 aa
12.1 kDa 		No 0
FEZ1-017
ENSP00000463116
ENST00000577924
J3KTR6 [Direct mapping]
Fasciculation and elongation protein zeta-1
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Show all
 207 aa
23.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.