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Cases of ovarian cancer, malignant lymphomas and melanomas showed nuclear and cytoplasmic positivity. Remaining malignancies were weakly stained or negative.
GENE INFORMATION
Gene name
TAGLN (HGNC Symbol)
Synonyms
DKFZp686P11128, SM22, SMCC, TAGLN1, WS3-10
Description
Transgelin (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)